Abstract：Objective: To study curative efficacy of GnRH-a combined with LNG-IUS in treatment of uterine adenomyosis and its effects on level of CA125,VEGF,FSH and LH. Methods: 60 patients of uterine adenomyosis who received therapy from June 2015 to June 2017 in our hospital were selected as research objects. According to the different treatment plan divided into observation group and control group, the control group to hysterectomy, the observation group given GnRH-a combined with LNG-IUS treatment. The levels of serum CA125, VEGF, FSH and LH were measured before and after treatment, and the dysmenorrhea, uterine volume and menstrual flow were observed. Results: After treatment, the total effective rate (90.0%) in the observation group was significantly higher than that in the control group (73.3%) (P<0.05). The levels of serum CA125, VEGF, FSH and LH were significantly lower than those in the control group (P<0.05). The incidence of dyspepsia in the observation group was significantly lower than that in the control group (P<0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P<0.05) The reaction rate was 26.7%, and the difference was significant (P<0.05). Conclusion: Shenfu injection unite recombinant human brain natriuretic peptide treatment of patients with chronic heart failure can effectively improve on cardiac function, the BNP, mmp-9, CypA levels were to reduce, significantly improve the clinical curative effect, and can reduce adverse reaction. GnRH-a combined with LNG-IUS treatment of patients with AM, effectively reduce serum CA125, VEGF, FSH and LH levels and reduce dysmenorrhea rating, uterine volume and menstrual score, and can reduce adverse reactions.
齐进,邓晓红. GnRH-a联合LNG-IUS对子宫腺肌症患者血清CA125 VEGF FSH LH的影响[J]. 河北医学, 2018, 24(10): 1615-1618.
QI Jin, DENG Xiaohong. Effect of GnRH-a combined with LNG-IUS on Serum CA125 VEGF FSH and LH in Patients with Adenomyosis. HeBei Med, 2018, 24(10): 1615-1618.
2018, Vol. 24 
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