Abstract：Objective: To compare the clinical effect of total endoscopic surgery and traditional surgical treatment for early differentiated thyroid adenocarcinoma. Methods: 92 cases of early differentiated thyroid adenocarcinoma treated in our hospital from January 2014 to June 2017 were retrospectively analyzed. According to different treatment methods, they were divided into control group (n=48) and study group (n=44). The control group was treated with traditional surgery, and the study group was treated with total endoscopic surgery. The operation condition, stress reaction, complications, cosmetic effect and follow-up of the two groups were compared. Results: Operation time, postoperative 24 hours flow rate in research group were more than the control group, incision length, intraoperative blood loss, postoperative 24 hours VAS and length of hospital stay were lower than the control group, there was statistically significant differences (P<0.05), central lymph node dissection between two group was no difference (P>0.05). 12h, 24h after surgery, the CD4+, CD4+/CD8+ in both group were lower, the research group were higher than the control group, CD8+, c-reactive protein (CRP) and interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) in both group were rised, the research group were lower than the control group, there was a statistically significant difference between the two groups in postoperative 12h and 24h (P<0.05). Total complication rate in both group was no statistical difference (P>0 0.05). The total satisfaction of research group was higher than that of the control group (P<0.05). during the follow-up, there was no tumor recurrence and metastasis in both groups, and there was no statistical difference (P>0.05). Conclusion: Long-term efficacy of total endoscopic surgery in the treatment of early differentiated thyroid adenocarcinoma is similar with traditional surgical treatment, however, full-endoscopic surgery has advantages, such as beauty and minimally invasive surgery, it's a better technique for patients with this indication.
邱洪波,唐乐,窦刚,侯娟茹,任浩敏. 全腔镜手术与传统手术治疗早期分化型甲状腺腺癌的临床效果研究[J]. 河北医学, 2018, 24(10): 1610-1614.
QIU Hongbo, TANG Le, DOU Gang, et al. The Clinical Effect of Total Endoscopic Surgery and Traditional Surgical Treatment for Early Differentiated Thyroid Adenocarcinoma. HeBei Med, 2018, 24(10): 1610-1614.
[1] Keegan TH, Grogan RH, Parsons HM, et al. Sociodemographic disparities in differentiated thyroid cancer survival among adolescents and young adults in california[J]. Thyroid,2015,25(6):635~648. [2] Fulciniti F, Vuttariello E, Calise C, et al. Combined papillary and mucoepidermoid carcinoma of the thyroid gland: a possible collision tumor diagnosed on fine-needle cytology. Report of a case with immunocytochemical and molecular correlations[J]. Endocr Pathol, 2015,26(2):140~144. [3] 樊华, 李健.甲状腺癌的临床诊治特点及治疗效果比较分析[J].实用癌症杂志,2016,31(3):503~505. [4] 张春霞,杨丽,王文超.手术治疗分化型甲状腺癌76例临床分析[J].现代肿瘤医学,2016,24(5):724~726. [5] 吕一峰.不同手术方法治疗分化型甲状腺癌178例分析[J].实用临床医药杂志,2015,19(13):88~89. [6] 中国抗癌协会头颈肿瘤专业委员会.分化型甲状腺癌诊治指南[J].中国实用外科杂志,2011,31(10):908~914. [7] 梅俊,罗高潮.腔镜辅助手术与开放性手术治疗早期甲状腺癌的疗效比较[J].中国现代普通外科进展,2017,20(1):53~54. [8] 李思齐,吴涛,李燕,等.不同手术方法治疗早期分化型甲状腺癌的临床效果比较[J].昆明医科大学学报,2017,38(2):109~113. [9] 田志龙,王小凯,高新宝,等.单侧早期分化型甲状腺乳头状癌不同切除术式的临床对比研究[J].腹腔镜外科杂志,2016,21(4):259~262. [10] 张雨胜.不同手术方式对分化型甲状腺癌治疗的临床效果及其影响因素分析[J].实用癌症杂志,2016,31(9):1534~1536. [11] 王薇,潘金强,陈辉,等.完全腔镜下甲状腺癌根治术与传统开放手术的临床效果对比分析[J].肿瘤学杂志,2017,23(12):1127~1130. [12] 王薇,岳翔,潘金强,等.完全腔镜下甲状腺癌根治术与传统开放性甲状腺癌根治术对机体应激反应的比较[J].新疆医科大学学报,2017,40(11):1428~1430. [13] 周小栋,黄小娥,鲁科斌,等.全腔镜下手术对早期分化型甲状腺癌患者T细胞亚群及其细胞因子的影响[J].中华全科医学,2016,14(12):2011~2013. [14] Gurgul E, Kasprzak A, Blaszczyk A, et al. Ghrelin and obestatin in thyroid gland - immunohistochemical expression in nodular goiter, papillary and medullary cancer[J]. Folia Histochem Cytobiol,2015,53(1):19~25.
2018, Vol. 24 
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