Abstract：Objective: To explore the effect of gatifloxacin in treatment urinary tract infection and its effect on serum PCT, IL-2 and IL-8. Methods: 122 patients with urinary tract infection who received therapy from June 2016 to December 2017 in two hospitals, according to the simple random number table method, those patients were divided into the control group and the research group, 61 cases in each group. control group was treated with levofloxacin, and the research group was treated with gatifloxacin. Then clinical efficacy, symptom relief time, the level of serum PCT, IL-2 and IL-8, and adverse reactions between two group was compared. Results: Total effective rate and bacterial clearance rate in research group was higher than that of the control group (P<0.05). the urinary tract pain, urinary frequency, and urgency relief time in research group was lesser than those in the control group, and there were statistically significant differences (P<0.05). Before treatment, serum PCT, IL-2 and IL-8 in two group was no statistically significant difference (P>0.05). After treatment, the levels of serum PCT and IL-8 in two group was decreased, and the level of IL-2 was significantly increased, and the changes of the research group were more obvious, there are statistically significant differences (P<0.05). adverse reactions in two group were mainly rash, dizziness and gastrointestinal discomfort, Adverse reaction rate in two group was no statistically significant (P>0.05). Conclusion: Effect of gatifloxacin in treatment urinary tract infection is sure, and can regulate the expression of serum PCT, IL-2 and IL-8, and reduce clinical symptoms, which may be a reliable solution for clinical treatment.
王琦, 梁京津. 加替沙星治疗泌尿系统感染的疗效及对血清PCT IL-2 IL-8的影响[J]. 河北医学, 2018, 24(9): 1540-1543.
WANG Qi, et al. Influnce of Gatifloxacin on Urinary Tract Infection and Its Effect on Serum PCT IL-2 and IL-8. HeBei Med, 2018, 24(9): 1540-1543.
[1] Park JI, Bliss DZ, Chi CL, et al. Factors associated with healthcare-acquired catheter-associated urinary tract Infections: analysis using multiple data sources and data mining techniques[J].Wound Ostomy Continence Nurs, 2018,45(2):168~173. [2] 葛洪娣.加替沙星与左氧氟沙星治疗泌尿系统感染的临床分析[J].解放军预防医学杂志,2016,34(S2):225. [3] Lewandowski DE, Pierce D, Barnett A, et al. Impact of antibiotic prophylaxis on catheter-associated urinary tract infections during atrial fibrillation ablation[J].Interv Card Electrophysiol, 2018,51(2):183~187. [4] Ortiz-Mendoza CM. An exceptional source of recurrent urinary tract infections in women: Primary retroperitoneal serous cystadenoma[J]. Taiwan Obstet Gynecol, 2018,57(1):168~170. [5] 王家菁,陈永华,杨盛,等.血尿安胶囊、左氧氟沙星治疗泌尿系感染疗效对比[J].中国中西医结合肾病杂志,2017,18(01):59~60. [6] 杜晖,范菲,李静静,等.左氧氟沙星与环丙沙星治疗泌尿系统感染疗效与安全性比较的Meta分析[J].药物流行病学杂志,2017,26(01):3~7. [7] Dawn A, Chandra H, Ade-Browne C, et al. Multifaceted supramolecular interactions from C-methylresorcin arene lead to an enhancement in in vitro antibacterial activity of gatifloxacin[J]. Chemistry, 2017,23(72):18171~18179. [8] Helmy SA. Simultaneous quantification of linezolid, tinidazole, norfloxacin, moxifloxacin, levofloxacin, andgatifloxacin in human plasma for therapeutic drug monitoring and pharmacokinetic studies in human volunteers[J]. Ther Drug Monit, 2013,35(6):770~777. [9] Venkataraman R, Divatia JV, Ramakrishnan N, et al. Multicenter observational study to evaluate epidemiology and resistance patterns of common intensive care unit-infections[J]. Indian Crit Care Med, 2018,22(1):20~26. [10] Chiang CY, Van Deun A, Rieder HL. Gatifloxacin for short, effective treatment of multidrug-resistant tuberculosis[J]. Int Tuberc Lung Dis, 2016,20(9):1143~1147.
2018, Vol. 24 
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