Abstract：Objective: To investigate the clinical efficacy of leuprolide combined with tibolone in the treatment of endometriosis. Methods: 80 patients with endometriosis admitted from October 2015 to October 2016 were randomly divided into two groups: leuprolide acetate group and leuprolide acetate group Boulong,. The clinical indicators, bone mineral density, overall treatment effect and Kupperman score of the two groups were compared. Results: The levels of 24wFSH (3.04 ± 0.53), LH (4.41 ± 0.73) and E2 (31.45 ± 6.33) in the combined group were significantly higher than those in the leuprolide group (2.38 ± 0.40,3.45 ± 0.70 , 25.78 ± 5.19), BGP (16.60 ± 4.17) and CA125 levels (13.27 ± 4.04) were significantly lower than those in the leuprolide group (24.17 ± 5.89 and 18.77 ± 4.60) The level of lumbar BMD at 6 months (1.085 ± 0.060) and 12 months after lumbar spine withdrawal (1.082 ± 0.061) were significantly higher than those in leuprolide group (1.035 ± 0.062,1.050 ± 0.051,1.054 ± 0.050) ; The total effective rate (87.5%) was significantly higher than that of leuprolide group (70%); after treatment, hot flashes, sweating value (5.90 ± 0.76), vulvar vaginal discomfort value (1.90 ± 0.55) (0.60 ± 0.18) and Kupperman score (7.94 ± 1.80) were lower than those in the leuprolide group (7.12 ± 0.88, 3.33 ± 1.08, 1.05 ± 0.42 and 10.77 ± 2.35 respectively), the difference was statistically significant (P <0.05). Conclusion: The clinical efficacy of leuprolide combined with tibolone in the treatment of endometriosis is significant, which can improve the safety and has reference value.
陈蓉, 王君, 刘月合. 醋酸亮丙瑞林联合反加替勃龙治疗子宫内膜异位症的临床疗效观察[J]. 河北医学, 2018, 24(8): 1354-1357.
CHEN Rong, WANG Jun, LIU Yuehe. Clinical Efficacy Observation of Leuprolide Acetate Combined with Tibolone in the treatment of Endometriosis. HeBei Med, 2018, 24(8): 1354-1357.
[1] 杨娇娇.探讨醋酸亮丙瑞林联合莉芙敏治疗子宫内膜异位症的临床效果和安全性[J].海峡药学,2017,29(10):172~173. [2] 王晶,陈滢,杨赛花.腹腔镜手术前后联合醋酸亮丙瑞林治疗子宫内膜异位症的比较研究[J].中国微创外科杂志,2011,16(6):492~495. [3] 谢幸,苟文丽.妇产科学[M].第8版.北京.人民卫生出版社,2013.150~154. [4] 李彩辉,朱慧芳,翟悦静,等.腹腔镜切除术后应用桂枝茯苓胶囊联合醋酸亮丙瑞林治疗子宫内膜异位症的临床观察[J].中国药房,2016,27(27):3807~3809. [5] Soliman Ahmed M,Bonafede Machaon,Farr Amanda M,et al.Analysis of subsequent surgery rates among endometriosis patients who underwent surgery with and without concomitant leuprolide acetate therapy.[J].Current medical research and opinion,2016,32(6):1073~1082. [6] Atsushi Kiba,Kouji Banno,Megumi Yanokura,et al.Differential mRNA expression profiling in ovarian endometriotic tissue with versus without leuprolide acetate treatment[J].Journal of Obstetrics and Gynaecology Research,2015,41(10):1598~1606. [7] Kenan Dolapcioglu,Gokhan Dogruer,Sule Ozsoy,et al.Theranekron for treatment of endometriosis in a rat model compared with medroxyprogesterone acetate and leuprolide acetate[J].European Journal of Obstetrics and Gynecology,2013,170(1):206~210. [8] 金夏,周虎,桂云,等.醋酸亮丙瑞林缓释微球治疗子宫内膜异位症的疗效[J].中国妇幼保健,2012,27(19):2917~2920. [9] 周明辉.反向添加疗法在子宫内膜异位症治疗中的临床意义[J].中国处方药,2015,14(7):118~119. [10] 陈勇霞,何风仪,刘颖.不同时机启动反向添加疗法对子宫内膜异位症术后促性腺激素释放激素类似物治疗的影响[J].广东医学,2013,34(7):1107~1109.
2018, Vol. 24 
冀公网安备13080202000677号