立体定向微创手术辅以术后吡拉西坦和高压氧治疗脑肿瘤的临床疗效观察

doi:10.3969/j.issn.1006-6233.2018.08.028

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摘要 目的: 分析立体定向微创手术结合术后吡拉西坦和高压氧治疗对脑肿瘤的临床疗效。 方法: 104例脑肿瘤患者采用随机数字表法分为对照组与观察组,各52例。给予对照组单纯的立体定向微创手术治疗,观察组予以立体定向微创手术后结合吡拉西坦及高压氧治疗。分析两组的生活质量评分、不良反应、疗效及随访1年的生存率、死亡率、复发率和转移率。 结果: 治疗期间,观察组并发症总发生率为7.67%,随访期间死亡率、复发率和转移率分别为11.54%、1.92%、1.92%,均明显低于对照组的21.15%、19.23%、13.46%、13.46%(P<0.05)。治疗后,观察组生活质量总评分(89.04±7.78)分,治疗总有效率92.31%,生存率为90.38%,均明显高于对照组(69.17±6.74、78.85%、53.85%)(P<0.05)。 结论: 脑肿瘤患者在立体定向微创手术后给予吡拉西坦和高压氧治疗的效果显著,可有效改善患者生活质量,降低并发症的发生,安全性高。

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	唐韬

关键词 ：脑肿瘤, 立体定向微创手术, 吡拉西坦, 高压氧

Abstract：Objective: To analyze the clinical efficacy of stereotactic micro-invasive surgery combined with postoperative piracetam and hyperbaric oxygen therapy for brain tumors. Methods: 104 cases of brain tumor patients were divided into control group and observation group according to admission by random digital table method, each group of 52 cases. The control group was treated with stereotactic minimally invasive surgery. The observation group was given stereotactic minimally invasive surgery combined with piracetam and hyperbaric oxygen therapy. The quality of life score, adverse reactions, curative effect and survival rate, mortality, recurrence rate and metastasis rate during the 1-year follow-up were and compared between the two groups. Results: During treatment, the total incidence of complications in the observation group was 7.67%, The mortality, recurrence rate and metastasis rate were 11.54%, 1.92%, 1.92% during follow-up, respectively, and these were significantly lower than the control group's (21.15%, 19.23%, 13.46%, 13.46%) (all P<0.05). After treatment, the total score of the life quality in the observation group was (89.04±7.78), the total effective rate was 92.31%, and the survival rate was 90.38%, which were significantly higher than those in the control group (69.17±6.74, 78.85%, 53.85%) (all P<0.05) . Conclusion: The effect of Laci Staw and hyperbaric oxygen therapy on brain tumor patients after minimally invasive surgery is significant. It can effectively improve the quality of life, reduce the incidence of complications, and have high safety.

Key words： Brain tumor Stereotactic minimally invasive surgery Piracetam Hyperbaric oxygen

基金资助:陕西省科技计划项目,(编号:2015K12-02-13)

引用本文:

唐韬. 立体定向微创手术辅以术后吡拉西坦和高压氧治疗脑肿瘤的临床疗效观察[J]. 河北医学, 2018, 24(8): 1336-1338.
TANG Tao. Observation on the Clinical Efficacy of Stereotactic Minimally Invasive Surgery Combined with Piracetam and Hyperbaric Oxygen in the Treatment of Brain Tumors. HeBei Med, 2018, 24(8): 1336-1338.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2018.08.028 或 http://www.hbyxzzs.cn/CN/Y2018/V24/I8/1336

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