Abstract：Objective: To investigate the relationship between plasma glucose and serum CA199 levels in physical examination people. Methods: A total of 2868 people aged 40-80 years were enrolled retrospectively from one medical center for physical examination of Hebei. According to CA199 level, all people were divided into negative group (<34U/ml) and positive group (≥34U/ml). Clinical data were compared between the two groups. The kinds of clinical data and the change of CA199 were compared according to different level of plasma glucose. Results: Compare with CA199 negative group, the levels of HbA1c, FPG, AST and ALT (P＜0.05) were significantly higher in CA199 positive group. The sex, age, BMI, SBP, DBP, TG, TC, LDL-C, HDL-C, BUN, Scr, SUA, γ-GGT, Hcy, WBC, NEUT, LYM between the two groups were no significant differences (P＞0.05). With the increase of HbA1c, the levels of CA199 were significantly higher (P＜0.01). Pearson analysis showed that the level of CA199 was positively correlated with FPG(r=0.272,P＜0.01), HbA1c(r=0.289, P＜0.01), AST(r=0.112, P＜0.01), ALT(r=0.087, P＜0.05). Multiple logistic regression analysis showed that FPG and HbA1c were associated with CA199 (OR=1.903,2.243,P=0.012,0.005) . Conclusion: The level of serum CA199 was affected by FPG and HbA1c in healthy people. Poor control of blood sugar was related to the increase of CA199.
聂倩, 王忠丽, 郝志华, 刘承浩. 健康体检人群血糖水平与血清CA199水平的相关性研究[J]. 河北医学, 2019, 25(2): 328-331.
NIE Qian, WANG Zhongli, HAO Zhihua, et al. The Relation between Plasma Glucose and Serum CA199 Levels in Physical Examination People. HeBei Med, 2019, 25(2): 328-331.
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2019, Vol. 25 
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