Abstract:Objective: To analyze whether there is a difference in cytogenetic between infertility patients of Bai and Han nationality in Dali. Methods: G-band karyotype analysis was carry on peripheral blood lymphocytes in 1056 couples with infertility (422 were Bai female and 417 were Bai male; 634 were Han female and 639 were Han male). Results: The number of Bai infertile patients who carried abnormal chromosomes were 44, the detection rate was 5.13%, including 24 females and 19 males. The number of Han infertile patients who had abnormal chromosomes were 118,the detection rate was 9.27%, including 72 females and 46 males. There was a statistically significant difference in the detection rate of abnormal karyotypes between the two ethnic groups, but there was no difference in the sex ratio the of the abnormal karyotypes between the two groups. Conclusion:. The abnormal karyotype detection rate of Bai infertility patients is lower than that of Han patients in Dali, Yunnan.That may be related to the marriage customs, education level, occupation and living habits of Bai people in Dali.
张丽蓉, 朱莉, 徐安莉, 吴睿. 云南大理地区白族和汉族不孕不育患者细胞遗传学分析[J]. 河北医学, 2019, 25(2): 325-327.
ZHANG Lirong, ZHU Li, XU Anli, et al. Cytogenetic Analysis of Infertility between Bai Nationality and Han Nationality in Dali Bai, Yunnan. HeBei Med, 2019, 25(2): 325-327.
[1] Feijo CM, Esteves SC.Diagnostic accuracy of sperm chromatin dispersion test to evaluate sperm deoxyribonucleic acid damage in men with unexplained infertility[J].Fertil Steril,2014, 101(1):58~63. [2] 王珺,苟兴庆,李丽,等.高龄患者行胚胎植入前遗传学筛查的有效性分析[J].中国优生与遗传杂志,2018,26(8):121~124. [3] 刘玲,刘迎春,顾珩,等.双酚A与不良妊娠结局的流行病学研究进展[J].环境与健康杂志,2017,34(7):654~657. [4] Jukic AM, Calafat AM, McConnaughey DR,et al.Urinary concentrations of phthalate metabolites and bisphenol a and associations with follicular-phase length, luteal-phase length, fecundability, and early pregnancy loss[J].Environ Health Perspect,2016,124(3):321~328. [5] 刘秀静,应晓媚,楼文文.女性不良妊娠与染色体异常关系探讨[J].中国优生与遗传杂志,2018,26(6):59~60. [6] Kissin DM, Zhang Y, Boulet SL, et al.Association of assisted reproductive technology (ART) treatment and parental infertility diagnosis with autism in ART-conceived children [J]. Hum Reprod, 2015,30(2):454~465.