Abstract：Objective: To compare the efficacy of erythropoietin (EPO), mild hypothermia and their combination in the treatment of hypoxic-ischemic encephalopathy in full-term neonates.Methods:This study was a clinical experimental study. From January 2015 to January 2018, 100 children with moderate to severe HIE were randomly divided into routine group, EPO group, routine + EPO group, mild hypothermia group, routine + mild hypothermia group, combined group, routine + EPO + mild hypothermia group, normal healthy newborn group. In the control group, there were 25 persons in each group. The changes of serum IL-6 and TNF-a at admission and 72 hours after admission were compared, and the changes of neonatal neurobehavioral (NBNA) scores at 3 and 14 days after admission were compared. Results: The expression levels of IL-6 and TNF-a in routine group, EPO group, mild hypothermia group, combination group and control group decreased gradually. There were significant differences between the two groups (P<0.05). The NBNA score of newborns in four groups increased gradually after 14 days of admission, and there were significant differences between the two groups (P<0.05). Conclusion: Among various treatments, erythropoietin combined with mild hypothermia had the lowest levels of IL-6 and TNF-a, and the highest neurobehavioral score of newborns, suggesting that brain injury was the lightest and recovery was the fastest. It had the best therapeutic effect on neonatal hypoxic-ischemic encephalopathy, reducing brain injury, protecting nervous system and improving prognosis.
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2019, Vol. 25 
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