Abstract：Objective: To explore the relationships between serum 25-hydroxyvitamin D and homocysteine (Hcy) with cognitive dysfunction in patients with Parkinson's disease. Methods: 132 cases of Parkinson's disease in our hospital from February 2014 to March 2018 were selected as observation group, and 75 cases of healthy physical examination were selected as control group, serum 25-hydroxyvitamin D and Hcy levels were detected, cognitive function was assessed by the Montreal cognitive assessment scale (MoCA), the correlations between serum 25-hydroxyvitamin D and Hcy levels with cognitive dysfunction were analyzed by Pearson correlation analysis, the risk factors of cognitive dysfunction were analyzed by unconditional logistic regression analysis. Results: The level of serum 25-hydroxyvitamin D in the observation group was significantly lower than that in the control group, while the level of Hcy was significantly higher than that in the control group (P<0.05); the executive ability, naming, attention, language, abstract thinking, delayed memory, directional ability and total score of the observation group were significantly lower than those of the control group (P<0.05); serum 25-hydroxyvitamin D was positively correlated with MoCA score, and Hcy level was negatively correlated with MoCA score (all P<0.05); the results of Logistic regression analysis showed that age, years of education, total cholesterol, triglyceride, diabetes, hypertension, 25-hydroxyvitamin D and Hcy were risk factors for cognitive impairment (P<0.05). Conclusion: The levels of serum 25-hydroxyvitamin D is significantly decreased in patients with Parkinson's disease, while Hcy is increased significantly, both of them are related to cognitive dysfunction,detection of 25-hydroxyvitamin D and Hcy levels is of great importance for early diagnosis and treatment of Parkinson's disease.
刘贵安, 时晶. 帕金森病患者血清25-羟维生素D Hcy水平与认知功能障碍的关系[J]. 河北医学, 2019, 25(2): 201-204.
LIU Guian, SHI Jing. The Relationships Between Serum 25-Hydroxyvitamin D and Hcy with Cognitive Dysfunction in Patients with Parkinson's Disease. HeBei Med, 2019, 25(2): 201-204.
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2019, Vol. 25 
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