Abstract：Objective: To analyze the diagnostic value of combined detection of serum human chorionic gonadotropin (β-HCG), high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) for premature rupture of membranes with intrauterine infection. Methods: 82 pregnant women with premature rupture of membranes diagnosed in the hospital from June 2016 to June 2017 were divided into the infected group and the control group according to the presence of intrauterine infection. The fasting venous blood samples of both groups were collected to detect levels of serum β-HCG, hs-CRP and IL-6. The critical values of the three serum indicators were determined according to the receiver operating characteristic (ROC) curve. Prediction and diagnosed of intrauterine infection were performed. Results: Of the 82 pregnant women with premature rupture of membranes, 38 cases (46.34%) had intrauterine infection, including 15 cases of mild infection, 15 cases of moderate infection and 8 cases of severe infection. Compared with the control group, levels of serum β-HCG, hs-CRP and IL-6 were significantly higher in the infected group (P<0.05). Levels of serum β-HCG, hs-CRP and IL-6 showed pregnant women with mild intrauterine infection < moderate infection < sever infection (P<0.05). According to the ROC curves, the diagnostic thresholds of serum β-HCG, hs-CRP and IL-6 were 3.32 ng/mL, 4.09 mg/L and 14.15 mg/L, respectively. The sensitivity, specificity and accuracy of combined detection of the three serum indicators in diagnosis of intrauterine infection were 92.11%, 90.91%and 91.46%, respectively, higher than those any indicator alone (P<0.05). Conclusion: The levels of serum β-HCG, hs-CRP and IL-6 are significantly higher in pregnant women with premature rupture of membranes and intrauterine infection than in uninfected pregnant women, and they are closely related to the severity of infection. Combined detection of the three serum indicators can improve the diagnostic efficiency for premature rupture of membranes with intrauterine infection.
李洁. 血清β-HCG hs-CRP IL-6联合检测对胎膜早破合并宫内感染的诊断价值分析[J]. 河北医学, 2019, 25(2): 182-185.
LI Jie. Diagnostic Value of Combined Detection of Serum β-HCG hs-CRP and IL-6 for Premature Rupture of Membranes with Intrauterine Infection. HeBei Med, 2019, 25(2): 182-185.
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2019, Vol. 25 
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