Abstract：Objective: To study the correlation between serum levels of microRNA-145 and insulin-like growth factor-1 receptor (IGF1R) and carotid artery stenosis in elderly patients with cerebral infarction. Methods: 181 elderly patients with cerebral infarction admitted to our hospital from March 2016 to March 2018 were divided into 47 patients with no stenosis of carotid artery and 134 patients with stenosis of carotid artery according to the results of carotid ultrasonography. 134 patients with carotid stenosis were divided into mild group (52 cases), moderate group (43 cases) and severe group (39 cases) by NASCET. Serum levels of miR-145 and IGF1R were measured. The changes of serum levels of miR-145 and IGF1R in patients with different degrees of carotid artery stenosis were analyzed. The risk factors of carotid artery stenosis in elderly patients with cerebral infarction were analyzed. Results: The relative expression of serum microRNA-145 in stenosis group was significantly lower than that in non-stenosis group, and the level of serum IGF1R was significantly higher than that in non-stenosis group (P<0.05). Serum microRNA-145 decreased gradually with the severity of carotid stenosis (P<0.05). Serum IGF1R level increased with the severity of carotid stenosis (P<0.05). Serum microRNA-145 level was negatively correlated with IGF1R level (r=0.539, P=0.000). Mir-145 was a protective factor for carotid stenosis, and IGF1R was a risk factor for carotid stenosis. Conclusion: The expression of serum microRNA-145 is down-regulated and the level of IGF1R is significantly increased in elderly patients with cerebral infarction, which is closely related to the degree of carotid artery stenosis and could be used as a therapeutic target for elderly patients with cerebral infarction.
何强华, 汪毅宏, 刘强, 李岚欣. 老年脑梗死患者miR-145 IGF1R水平与颈动脉狭窄的相关性[J]. 河北医学, 2019, 25(1): 131-134.
HE Qianghua, WANG Yihong, LIU Qiang, et al. The Correlation between the Levels of miR-145 and IGF1R and Carotid Artery Stenosis in Elderly Patients with Cerebral Infarction. HeBei Med, 2019, 25(1): 131-134.
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2019, Vol. 25 
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