Abstract：Objective: To study the effects of dexmedetomidineon the plasma high sensitive C reactive protein(hs-CRP), procalcitonin(PCT), interleukins(IL-6), thoracic Fluid(TFC) levels and Oxygenation of Patients with ARDS Induced by Sepsis. Methods: A total of 62 ARDS patients with sepsis admitted to intensive care unit from February 2016 to February 2018 were divided into observation group (n =32) and control group (n = 30) by simple random number table method. On the basis of conventional mechanical ventilation, the control group was given midazolam sedative treatment, while the observation group was given dexmedetomidine sedative treatment, they were combined with fentanyl for analgesia. The clinical efficacy and levels of plasma hs-CRP, PCT, IL-6, TFC, oxygenation index and acute physiology and chronic health scoring system II (APACHE II) score before and after treatment and the ICU length of stay, weaning time and fatality ratewere recorded. Results: After treatment,the total effective rate of the observation group was significantly higher than that of the control group(P<0.05). The reduction amplitude of the plasma hs-CRP, PCT, IL-6, TFC, APACHE II scores in the observation group were significantly higher than those in the control group (P<0.05), the increase amplitude of the SaO2, PaO2 PaO2/FiO2 were also significantly higher than those of the control group (P<0.05). The ICU length of stay and weaning time of the observation group were significantly shorter than those of the control group, and the mortality was significantly lower than that of the control group (P<0.05). Conclusion: Dexmedetomidine sedation can reduce the levels of hs-CRP, PCT, IL-6 and TFC in plasma of sepsis-induced ARDS patients, alleviate inflammation, improve oxygenation index, shorten ICU hospitalization time and reduce mortality.
郑春, 简万均, 朱俊. 右美托咪定对脓毒症致ARDS患者血浆hs-CRP PCT IL-6 TFC及氧合指标的影响[J]. 河北医学, 2019, 25(1): 94-98.
ZHENG Chun, et al. Effects of Dexmedetomidine on the Plasma hs-CRP PCT IL-6 TFC levels and Oxygenation of Patients with ARDS Induced by Sepsis. HeBei Med, 2019, 25(1): 94-98.
2019, Vol. 25 
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