依沙吖啶联合地诺前列酮对产妇宫颈Bishop评分 PGE2α ET-1水平及妊娠结局影响

doi:10.3969/j.issn.1006-6233.2018.07.041

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摘要 目的: 研究依沙吖啶联合地诺前列酮对产妇宫颈Bishop评分、PGE2α、ET-1水平及妊娠结局影响。 方法: 选取2015年4月至2016年3月我院收治的86例产妇,按照患者入院顺序分为观察组和对照组,43例每组。对照组采用地诺前列酮完成治疗,观察组在此基础上加以依沙吖啶完成治疗。比较两组患者宫颈成熟情况,Bishop评分、PGE2α、ET-1水平,引产情况。 结果: 治疗后,观察组产妇的宫颈Bishop评分显著高于对照组(9.21±0.96 vs5.98±0.62 P<0.05),3d内宫颈成熟情况显著优于对照组[93.02%(40/43) vs 72.09%(31/43)P<0.05]。观察组的PGE2α、ET-1水平显著高于对照组[(8.78±0.82 vs 6.97±0.68 P<0.05)、(3.26±0.38 vs 2.96±0.29 P<0.05)]。观察组的胎儿窘迫率、剖宫产率显著低于对照组[4.65%(2/43)vs 25.58%(11/43)、6.98%(3/43)vs 27.91%(12/43)](P<0.05)。观察组和对照组的不良反应率比较无显著差异[2.32%(1/43)vs 4.65%(2/43)](P>0.05)。 结论: 依沙吖啶联合地诺前列酮可有效促进产妇宫颈成熟,提高PGE2α、ET-1水平,能有效改善妊娠结局。

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	孟庆堂
	叶青
	吴修娟

关键词 ：依沙吖啶, 地诺前列酮, 妊娠结局

Abstract：Objective: To study the effects of ethacridine combined with dinoprofenone in treatment of maternal cervix and its effects on Bishop score, PGE2α, ET-1 level and pregnancy outcome. Methods: From April 2015 to March 2016, 86 pregnant women admitted in our hospital, randomly divided into observation group and control group, 43 cases per group. The control group was treated with dinoprofen, and the observation group was treated ethacridine on the basis of control group. The two groups of patients with cervical ripening, Bishop score, PGE2α, ET-1 levels, induction of labor were compared. Results: After treatment, the cervical Bishop score of the observation group was significantly higher than that of the control group(9.21±0.96 vs5.98±0.62 P<0.05), and the cervical ripening within 3 days was significantly better than that of the control group [93.02%(40/43) vs 72.09%(31/43)P<0.05]. The levels of PGE2α and ET-1 in the observation group were significantly higher than those in the control group [(8.78±0.82 vs 6.97±0.68 P<0.05), (3.26±0.38 vs 2.96±0.29 P<0.05)]. The rate of fetal distress and breaking rate in the observation group was significantly lower than that in the control group [4.65%(2/43)vs 25.58% (11/43)、6.98%(3/43)vs 27.91%(12/43)](P<0.05). There was no significant difference in the adverse reaction rate between the observation group and the control group [2.32%(1/43)vs 4.65%(2/43)](P>0.05). Conclusion: Ethacridine combined with dinoprofen can effectively promote maternal cervical maturation and improve the level of PGE2α and ET-1, which can effectively improve the outcome of pregnancy.

Key words： Ethacridine Dinoprofen Pregnancy outcome

基金资助:山东省自然科学基金资助项目,(编号:2014CM136)

引用本文:

孟庆堂, 叶青, 吴修娟. 依沙吖啶联合地诺前列酮对产妇宫颈Bishop评分 PGE2α ET-1水平及妊娠结局影响[J]. 河北医学, 2018, 24(7): 1219-1222.
MENG Qingtang, YE Qing, WU Xiujuan. Effects of Ethacridine combined with Dinoprofen in treatment of Maternal Cervix and its Influcences on Bishop score, PGE2α, ET-1 level and Pregnancy outcome. HeBei Med, 2018, 24(7): 1219-1222.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2018.07.041 或 http://www.hbyxzzs.cn/CN/Y2018/V24/I7/1219

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