Abstract：Objective: To explore the application of nalbuphine combined with suprainguinal fascia iliaca block (SIFIB) in anesthesia of patients undergoing total hip arthroplasty (THA). Methods: A retrospective analysis was cnducted on 96 hip fracture patients admitted from August 2021 to December 2023. According to different anesthesia methods, all patients were divided into SIFIB group (n=48) and nalbuphine group (n=48). The hemodynamics, perioperative indicators, pain interference in resting state and dynamic state, sedation and adverse reactions of anesthetic drugs were compared between groups. Results: Heart rate (HR) and median arterial pressure (MAP) in the both groups showed upward trends and then downward trends, and HR and MAP at T1-T3 in nalbuphine group were significantly lower than those of SIFIB group (P<0.05). The duration of analgesia in nalbuphine group was significantly longer than that in SIFIB group (P<0.05), and the frequency of pain interference in nocturnal sleep was significantly less (P<0.05). Visual analogue scale (VAS) scores in the both groups were significantly decreased, VAS scores at different time points were significantly decreased in nalbuphine group than SIFIB group (P<0.05). There was no significant difference in the Ramsay score at intergroup comparison, time point comparison, and group×time interaction between groups (P>0.05). No significant difference was found in the incidence of adverse drug reaction between groups (P>0.05). Conclusion: Nalbuphine combined with SIFIB can improve the anesthesia quality in THA patients. It has good analgesic and sedative effects and is safe and effective, with a worthy of application.
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2025, Vol. 31 
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