Abstract：Objective: To analyze the relationship between serum levels of interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), and nitric oxide (NO) and postoperative remission in patients with patent foramen ovale (PFO)-related migraine. Methods: A total of 105 patients with PFO-related migraine who underwent interventional occlusion at our hospital from May 2020 to May 2023 were included in the study. Serum levels of IL-1β, COX-2, and NO were measured 3 days after surgery. Patients were followed up for 1 month postoperatively and divided into a remission group (n=65) and a non-remission group (n=40) based on symptom relief. The predictive value of serum IL-1β, COX-2, and NO levels for postoperative remission was evaluated using receiver operating characteristic (ROC) curve analysis. Results: Serum levels of IL-1β, COX-2, and NO were significantly higher in the non-remission group compared to the remission group (P<0.05). ROC curve analysis revealed that the combination of serum IL-1β, COX-2, and NO levels had an area under the curve (AUC) of 0.895, with a sensitivity of 85.00% and a specificity of 87.69% for predicting postoperative remission. The combined predictive efficiency was superior to that of each individual indicator (P<0.05). Conclusion: Serum levels of IL-1β, COX-2, and NO are closely associated with postoperative remission in patients with PFO-related migraine. Early postoperative measurement of these biomarkers may provide valuable predictive insights into patient outcomes.
梁立龙, 熊凌杰. IL-1β COX-2 NO水平与卵圆孔未闭相关偏头痛患者术后缓解的关系分析[J]. 河北医学, 2025, 31(3): 486-489.
LIANG Lilong, XIONG Lingjie. Analysis of the Relationship Between IL-1β COX-2 and NO Levels and Postoperative Remission in Patients with Patent Foramen Ovale-Related Migraine. HeBei Med, 2025, 31(3): 486-489.
2025, Vol. 31 
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