Abstract：Objective: To analyze the relationship between arteriosclerosis indicators, plasma alarin, insulin-like growth factor-1 (IGF-1) with frailty in elderly patients with coronary heart disease (CHD). Methods: A retrospective analysis was conducted on the data of 102 elderly patients with CHD in the hospital from May 2020 to May 2024. All patients underwent artery ultrasound examination and testing of plasma alarin and IGF-1. According to the Fried Frailty score, the subjects were divided into frailty group and non-frailty group. Baseline date, arteriosclerosis indicators, plasma alarin and IGF-1 were compared between the two groups. The correlation between arteriosclerosis indicators, plasma alarin, IGF-1 with frailty was analyzed. Results: According to the Fried Frailty score, 42 (40.78%) patients with scores of 3 or above were included in the frailty group, and 60 (58.82%) patients with scores below 3 in the non-frailty group. Intima-media thickness (IMT), cardio-ankle index, and plasma alarin levels in the frailty group were significantly higher than those of the non-frailty group, while IGF-1 levels were significantly lower (P<0.05). Multivariate logistic regression analysis showed that IMT (OR=1.134, 95%CI: 1.020~1.261), cardio-ankle index (OR=1.522, 95%CI: 1.078~2.149), plasma alarin (OR=1.065, 95%CI: 1.008-1.125), and IGF-1 (OR=0.599, 95%CI: 0.394~0.912) were influencing factors of frailty in elderly patients with CHD (P<0.05). Receiver operating characteristic (ROC) curves indicated that the area under the curve (AUC) of IMT, cardio-ankle index, plasma alarin, and IGF-1 for predicting frailty in elderly patients with coronary heart disease was 0.746 (0.650-0.827), 0.723 (0.626-0.807), 0.674 (0.574-0.763), and 0.739 (0.643-0.821), respectively. The AUC of the combination of above indicators was 0.857 (0.774-0.919), which was significantly higher than that of each indicator (Z=2.518, 2.675, 3.238, 2.530, P<0.05). Conclusion: Arteriosclerosis indicators, plasma alarin, and IGF-1 are elevated in elderly patients with CHD and frailty. Besides, arteriosclerosis indicators and plasma alarin are positively correlated with frailty, and IGF-1 expression was negatively correlated with frailty. These indicators can be used for evaluating frailty in elderly patients with CHD.
2025, Vol. 31 
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