Abstract：Objective: To investigate the relationship and clinical significance of serum signal transducer and activator of transcription 3 (STAT3) and bilirubin/albumin ratio with the severity of neonatal jaundice. Methods: A total of 320 neonatal jaundice patients treated at our hospital from September 2023 to April 2024 were enrolled as the observation group, including 184 cases of physiological jaundice and 136 cases of pathological jaundice. Based on serum total bilirubin levels, the patients were further divided into mild (96 cases), moderate (164 cases), and severe (60 cases) groups. Additionally, 320 healthy newborns undergoing physical examinations during the same period were selected as the control group. Serum STAT3 levels were measured using enzyme-linked immunosorbent assay (ELISA), while total bilirubin and albumin levels were detected using a fully automated biochemical analyzer to calculate the bilirubin/albumin ratio. Spearman correlation analysis was used to assess the relationship between serum STAT3 levels, bilirubin/albumin ratio, and disease severity. Multivariate logistic regression analysis was performed to identify factors influencing disease severity. Receiver operating characteristic (ROC) curves were plotted to evaluate the predictive value of serum STAT3 levels and bilirubin/albumin ratio for therapeutic efficacy in neonatal jaundice. Results: Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (GGT) in the observation group were significantly higher than those in the control group (P<0.05). Serum STAT3 levels and bilirubin/albumin ratio were significantly higher in pathological jaundice compared to physiological jaundice (P<0.05). These levels were also significantly elevated in mild, moderate, and severe jaundice groups compared to the control group (P<0.05). Spearman correlation analysis revealed a positive correlation between serum STAT3 levels, bilirubin/albumin ratio, and disease severity (P<0.05). Neonatal jaundice patients with poor therapeutic outcomes exhibited significantly higher serum STAT3 levels and bilirubin/albumin ratio before treatment and at 1, 3, 5, and 7 days post-treatment compared to those with good outcomes (P<0.05). ROC curve analysis demonstrated that the combined prediction of serum STAT3 levels and bilirubin/albumin ratio had a significantly larger area under the curve (AUC) for predicting therapeutic efficacy compared to STAT3 alone (Z=4.700, P<0.001) or bilirubin/albumin ratio alone (Z=4.324, P<0.001). Conclusion: Serum STAT3 levels and bilirubin/albumin ratio are significantly elevated in neonatal jaundice patients and are closely associated with disease severity and therapeutic efficacy.
牛素雯, 张新华, 杨瑛, 田静, 刘晓欢. 新生儿黄疸患儿血清STAT3胆红素/白蛋白比值与病情严重程度的关系及临床意义[J]. 河北医学, 2025, 31(3): 457-463.
NIU Suwen, ZHANG Xinhua, YANG Ying , et al. The Relationship and Clinical Significance of Serum STAT3 and Bilirubin/Albumin Ratio with Disease Severity in Neonatal Jaundice. HeBei Med, 2025, 31(3): 457-463.
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2025, Vol. 31 
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