Abstract：Objective: To analyze the clinical characteristics and risk factors associated with invasive Klebsiella pneumoniae liver abscess syndrome (IKPLAS).Methods: A retrospective analysis was conducted on the clinical data of 442 patients with Klebsiella pneumoniae liver abscess admitted to the Affiliated Hospital of Chengde Medical University from August 1, 2014, to June 31, 2023. The patients were divided into the IKPLAS group (431 cases) and the non-IKPLAS group (11 cases). Clinical features were compared between the two groups. Univariate and multivariate logistic regression analyses were used to identify risk factors for IKPLAS in Klebsiella pneumoniae liver abscess patients.Results: Univariate analysis indicated that diabetes, perihepatic abscess, neutrophil ratio, hemoglobin level, gas-containing abscess, and SOFA score were associated with the development of IKPLAS in patients with Klebsiella pneumoniae liver abscess. Multivariate logistic regression analysis identified diabetes at admission [OR=8.922 (95%CI: 1.676~47.505)], neutrophil ratio, and hemoglobin level as independent risk factors for IKPLAS, with OR values of 0.947 (95%CI:0.903~0.997) and 0.970 (95% CI:0.949~0.997), respectively.Conclusion: Diabetes, decreased neutrophil ratio, and reduced hemoglobin are independent risk factors for the development of IKPLAS in patients with Klebsiella pneumoniae liver abscess.
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2024, Vol. 30 
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