痰湿体质高脂血症合并抑郁症患者脂代谢指标血清尿酸与尿微量白蛋白水平的相关性分析

doi:10.3969/j.issn.1006-6233.2024.07.027

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摘要 目的: 分析痰湿体质高脂血症合并抑郁症患者脂代谢指标、血清尿酸与尿微量白蛋白水平的相关性。方法: 回顾性分析本院2021年7月至2023年7月收治的157例高脂血症合并抑郁症患者临床资料,另选取同期来院体检的健康人群120例作为对照组,对比两组一般人口学资料和实验室检测指标;按照抑郁程度分为轻度抑郁组(n=68)、中度抑郁组(n=56)和重度抑郁组(n=33),对比三组患者尿酸(UA)、尿微量白蛋白(mAlb)水平;根据高脂血症分型将患者分为Ⅰ型组(n=25)、Ⅱ型组(n=43)、Ⅲ型组(n=48)、Ⅳ型组(n=28)和Ⅴ型组(n=13),对比五组患者UA、mAlb水平;并采用Pearson相关性分析脂代谢指标、UA、mAlb水平之间的相关性。结果: 病例组总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)、载脂蛋白A(apoA)、载脂蛋白B(apoB)、UA、mAlb水平均高于对照组(P<0.05);病例组高密度脂蛋白(HDL-C)低于对照组(P<0.05)。不同程度抑郁症合并高脂血患者UA、mAlb水平比较均有统计学意义(P<0.05),均为轻度抑郁组<中度抑郁组<重度抑郁组(P<0.05)。157例高脂血症合并抑郁症患者中,Ⅰ型25例,Ⅱ型43例,Ⅲ型48例,Ⅳ型28例,Ⅴ型13例。Ⅰ型组UA、mAlb水平<Ⅱ型组<Ⅲ型组<Ⅳ型组<Ⅴ型组(P<0.05)。Pearson相关性分析结果显示:UA、mAlb均与TC、TG、LDL-C、apoA无显著相关性(P>0.05),与HDL-C呈负相关(r=-0.431、-0.260,P<0.05),与apoB呈正相关(r=0.413、0.428,P<0.05);UA、mAlb之间呈正相关(r=0.522,P<0.05)。结论: 血清脂代谢指标及UA、mAlb表达水平在高脂血症合并抑郁症患者中呈高表达,且三者与高脂血症合并抑郁症关系密切。

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关键词 ：痰湿体质, 高脂血症合并抑郁症, 脂代谢指标, 尿酸, 尿微量白蛋白

Abstract：Objective: To analyze the correlation of lipid metabolism, serum uric acid and urinary microalbumin in patients with phlegm-dampness constitution and hyperlipidemia complicated with depression. Methods: The clinical data of 157 patients with hyperlipidemia complicated with depression admitted to our hospital from July 2021 to July 2023 were retrospectively analyzed. In addition, 120 healthy people who came to the hospital for physical examination at the same time were selected as the control group. The general demographic data and laboratory test indicators [total cholesterol (TC), triacylglycerol (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), apolipoprotein A (apoA), apolipoprotein B (apoB), uric acid (UA), microalbumin (mAlb)] were compared between both groups. According to the degree of depression, the patients were divided into mild depression group (n=68), moderate depression group (n=56) and severe depression group (n=33), and the levels of UA and mAlb were compared among the three groups. By means of hyperlipidemia typing, the patients were divided into type Ⅰ group (n=25), type Ⅱ group (n=43), type Ⅲ group (n=48), type Ⅳ group (n=28) and type Ⅴ group (n=13). The levels of UA and mAlb among the five groups were compared. Pearson correlation was used to analyze the correlation between lipid metabolism, UA and mAlb. Results: TC, TG, LDL-C, apoA, apoB, UA, mAlb were significantly higher in patients than in control group (P<0.05) and HDL-C was significantly lower in patients than in control group (P<0.05).The levels of UA and mAlb in different degree of depression patients with hyperlipidemia were statistically significant (P<0.05), and the order was mild depression grouP<moderate depression grouP<severe depression group (P<0.05).Among the 157 patients with hyperlipidemia complicated with depression, 25 were type Ⅰ, 43 type Ⅱ, 48 type Ⅲ, 28 type Ⅳ and 13 type Ⅴ.The levels of UA and mAlb in different types of hyperlipidemia patients with depression were statistically significant (P<0.05), and the order was type Ⅰ grouP<type Ⅱ grouP<type Ⅲ grouP<type Ⅳ grouP<type Ⅴ group (P<0.05). Pearson correlation analysis showed that UA and mAlb were not significantly correlated with TC, TG, LDL-C and apoA (P>0.05), but were negatively correlated with HDL-C (r=-0.431, -0.260, P<0.05) and positively correlated with apoB (r=0.413, 0.428, P<0.05), and UA had positive correlation with mAlb (r=0.522, P<0.05). Conclusion: Serum lipid metabolism indexes and UA and mAlb expression levels are highly expressed in patients with hyperlipidemia complicated with depression, and they are closely related to hyperlipidemia complicated with depression.

Key words： Phlegm-dampness constitution Hyperlipidemia with depression Lipid metabolism index Uric acid Urinary microalbumin

基金资助:河北省中医药管理局科研计划项目,(编号:2022640)

通讯作者: 乔昱婷

引用本文:

闵妍, 刘美之, 吕润欣, 乔昱婷. 痰湿体质高脂血症合并抑郁症患者脂代谢指标血清尿酸与尿微量白蛋白水平的相关性分析[J]. 河北医学, 2024, 30(7): 1202-1206.
MIN Yan, et al. Correlation Analysis of Lipid Metabolism Index Serum Uric Acid and Urinary Microalbumin Level in Patients with Phlegm-dampness Constitution and Hyperlipidemia Complicated with Depression. HeBei Med, 2024, 30(7): 1202-1206.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2024.07.027 或 http://www.hbyxzzs.cn/CN/Y2024/V30/I7/1202

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