Abstract：Objective: To investigate the relationship between serum sex hormone levels and idiopathic scoliosis (AIS) in adolescent girls, as well as the relationship between sex hormones and the degree of scoliosis and bone mineral density (BMD). The feasibility and credibility of using sex hormones to identify the probability of AIS in adolescent girls were also analyzed. Methods: Thirty-eight adolescent females with AIS (AIS group) treated in our rehabilitation center from February 2018 to December 2023 were selected, and 29 age-matched females without AIS were recruited as the control group. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone, estradiol (E2), Cobb angle, trunk rotation angle, and BMD were measured. The correlation between sex hormone levels and BMD, scoliosis severity in AIS patients, and the value of using sex hormone levels to judge the probability of AIS in adolescent females were analyzed. Results: The serum LH level, Cobb angle, and trunk rotation angle in the AIS group were higher than those in the control group (t=4.532, 42.835, 23.808, P<0.05), while E2 and BMD were lower than those in the control group (t=2.814, 7.082, P<0.05). Serum LH in AIS patients was positively correlated with Cobb angle and trunk rotation angle (P<0.05) and negatively correlated with BMD (P<0.05). E2 levels were negatively correlated with Cobb angle and trunk rotation angle (P<0.05) and positively correlated with BMD (P<0.05). The area under the curve (AUC) for identifying AIS in adolescent females based on E2 and LH was 0.690 and 0.801, respectively. The AUC for identifying AIS in adolescent females based on a combination of E2 and LH was 0.807, which had an identification value (P<0.05), but the difference was not significant compared with the identification value of E2 or LH alone (P>0.05). Conclusion: Sex hormone levels are related to the occurrence of AIS in adolescent females and play an important role in the pathogenesis and progression of the disease. Observation of E2 and LH data alone or in combination can help to identify AIS and assess the severity of the condition.
韩雪, 王士安, 张玉华. 血清性激素水平与青春期女孩特发性脊柱侧弯的关系研究[J]. 河北医学, 2024, 30(7): 1181-1185.
HAN Xue, et al. Relationship between Serum Sex Hormone Levels and Idiopathic Scoliosis in Adolescent Females. HeBei Med, 2024, 30(7): 1181-1185.
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2024, Vol. 30 
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