Abstract:Objective: To investigate the efficacy of laparoscopic transumbilical single-site appendectomy (LTSSA) for pediatric appendicitis and its impact on inflammatory factors. Methods: The clinical data of pediatric appendicitis patients treated in our hospital from March 2022 to June 2023 were retrospectively analyzed. 55 patients who underwent LTSSA were randomly selected from the LTSSA group using a random number table, and 50 patients who underwent traditional laparoscopic appendectomy (LTA) were randomly selected from the LTA group using a random number table. The surgical parameters, postoperative recovery, and postoperative complications of the two groups were compared. The improvement of appendicitis symptoms before and 5 days after surgery [Appendicitis Inflammatory Response (AIR) score, Visual Analogue Scale (VAS) score] and the levels of inflammatory factors before, 48 hours after surgery and 5 days after surgery were compared. Results: The operation time, intraoperative bleeding volume, time of first postoperative flatus, time of normal body temperature recovery, time of getting out of bed and activity, length of hospital stay, and incidence of postoperative complications were all lower in the observation group than in the control group, with statistically significant differences (P<0.05). At 5 days after surgery, the AIR and VAS scores of the two groups were lower than before surgery, and the decrease in the observation group was greater than that in the control group, with statistically significant differences (P<0.05). Repeated measures ANOVA showed that the time point effect, group effect, time point and group interaction effect of the two groups of patients after surgery can all affect the changes in CRP, PCT, and WBC levels (P<0.05), and the observation group was lower than the control group, with statistically significant differences (P<0.05). Conclusion: LTSSA for pediatric appendicitis has a positive effect, reduces postoperative complications, lowers inflammatory factor levels, and helps in the rapid recovery of patients.