Abstract：Objective: To investigate the changes and clinical significance of serum creatine kinase isoenzyme (CreatineKinase-MB, CKMB), neuropeptide Y (Neuropeptide Y, NPY), and β2-microglobulin (β2-microglobulin, β2-MG) levels in hyperbilirubinemic neonates.Methods: A total of 118 hyperbilirubinemic neonates admitted to our hospital from January 2019 to January 2022 were selected as the observation group. According to the total bilirubin (STB) level, they were divided into three groups: mild group (n=58, 220.6μmol/L≤STB≤256.5μmol/L), moderate group (n=42,256.5μmol/L≤STB≤342μmol/L), and severe group (n=18, STB>342μmol/L). Another 112 healthy neonates without jaundice who underwent percutaneous bilirubin measurement in our hospital during the same period were selected as the control group. The levels of CKMB, NPY, and β2-MG in the control group and observation group were compared. The levels of CKMB, NPY, and β2-MG in patients with different STB levels in the observation group were compared. According to the percutaneous bilirubin-measured STB level, the patients were divided into the acute phase group and the recovery phase group, and the levels of CKMB, NPY, and β2-MG in the two groups were compared.Results: The levels of CKMB, NPY, and β2-MG in the observation group were all higher than those in the control group (P<0.05). Comparison of CKMB, NPY, and β2-MG levels in patients with different STB levels: mild group < moderate group < severe group (P<0.05). Among the 118 hyperbilirubinemic neonates, there were 67 cases in the acute phase group and 51 cases in the recovery phase group. The levels of CKMB, NPY, and β2-MG in the acute phase group were all higher than those in the recovery phase group (P<0.05).Conclusion: Serum CKMB, NPY, and β2-MG levels are closely related to the severity and prognosis of hyperbilirubinemia in neonates. Monitoring these indicators can help assess the progression and prognosis of the condition, providing significant clinical value.
[1] 王旭荣,刘柳叶,张北宁,等.血清cTnI、CK-MB及IGF-1在新生儿高胆红素血症中的变化及临床意义[J].现代生物医学进展,2020,20(21):4101-4104. [2] Wang,Chen W,Xiaoreng T,et al.Traditional Chinese medicines alleviated myocardial ischemia by regulating Qi and promoting blood circulation[J].Journal of Traditional Chinese Medicine,2020,40(6):87-95. [3] 赖苑双,黎维丹,胡向国,等.高胆红素血症新生儿血红蛋白A、F与G-6-PD表达的相关性[J].暨南大学学报(自然科学与医学版),2019,40(5):411-418. [4] 唐炜,卢红艳,孙勤,等.高胆红素血症新生儿肠道菌群特点及与β-葡萄糖醛酸苷酶活性的相关性[J].中国当代儿科杂志,2021,23(7):677-683. [5] 段灵,陈 萍,胡红兵.直接抗球蛋白试验和总胆红素与白蛋白比值联合检测在ABO新生儿溶血病导致的严重高胆红素血症中的临床意义[J].临床输血与检验,2022,24(5):600-604. [6] 中华医学会儿科学分会新生儿学组,《中华儿科杂志》编辑委员会.新生儿高胆红素血症诊断和治疗专家共识[J].中华儿科杂志,2014,52(10):745-748. [7] 张捷宇,刘朝艳,马永倩,等.新生儿期黄疸患儿血清胆红素水平与苍白球1H-MRS特征的相关分析[J].放射学实践,2020,35(12):1600-1604. [8] A J D P,B M L,B D M M,et al.Clinical decision support for hyperbilirubinemia risk assessment in the electronic health record[J].Academic Pediatrics,2020,20(6):857-862. [9] 王萍,唐宋琪,陈应奇,等.血清NPY和IGF-1在成人OSAHS中的表达及与患者认知功能关系[J].西部医学,2020,32(3):426-429,437. [14] 贲英姿,陈晚琴,金爱琴,等.血清25-(OH)-D3、γ-GT、β2-MG水平与新生儿高胆红素血症患儿肾功能损伤及疾病严重程度的关系[J].河北医药,2021,43(5):697-700. [11] Yu D,Xiong J,Gao Y,et al.Resveratrol activates PI3K/AKT to reduce myocardial cell apoptosis and mitochondrial oxidative damage caused by myocardial ischemia/reperfusion injury[J].Acta Histochemica,2021,123(5):151739.
2024, Vol. 30 
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