Clinical Efficacy of Glutamine Combined with Erythropoietin in the Treatment of Necrotizing Enterocolitis in Premature Infants and Its Effect on Serum IL-6 TNF-α and i-FABP Levels
SUN Shiqi, PIAO Qian
The First Affiliated Hospital of China Medical University, Liaoning Shenyang 110001, China
Abstract：Objective: To investigate the clinical efficacy of glutamine combined with erythropoietin in the treatment of necrotizing enterocolitis (NEC) in premature infants and its effect on serum IL-6, TNF-α, and i-FABP levels. Methods: A retrospective analysis was conducted on 100 premature infants diagnosed with NEC in the Department of Neonatology, The First Affiliated Hospital of China Medical University from January 2020 to January 2022. According to the treatment methods received by the infants, they were divided into the observation group (n=50) and the control group (n=50). The observation group was treated with glutamine combined with erythropoietin, and the control group was treated with glutamine alone. The total effective rate, inflammatory reaction, i-FABP, immunoglobulin level, intestinal flora change, and drug safety of the two groups were recorded and observed. Results: The total effective rate of the observation group (92.00%) was significantly higher than that of the control group (70.00%), and the difference was statistically significant (P<0.05). Before treatment, there was no statistically significant difference in the levels of serum inflammatory factors, i-FABP, IgA, IgM, IgG, and the total number of bacteria, cocci, and bacilli in the stool specimens between the two groups (P>0.05). Compared with before treatment, the levels of serum IL-6, TNF-α and i-FABP in both groups decreased after 7 days of treatment, and the levels of IgA, IgM, IgG, the total number of bacteria, cocci, and bacilli in the stool specimens increased. The differences were statistically significant (P<0.05). There was a statistically significant difference in the changes of serum IL-6, TNF-α, i-FABP, IgA, IgM, IgG levels, and the total number of bacteria, cocci, and bacilli in the stool specimens before and after treatment between the two groups (P<0.05). During the one-month follow-up, there was no statistically significant difference in the adverse reactions between the two groups (P>0.05). Conclusion: On the basis of glutamine, combined erythropoietin can effectively improve the clinical efficacy of NEC in premature infants, reduce the levels of serum inflammatory factors and i-FABP, promote the stability of intestinal flora in premature infants, enhance the immunity of infants, and has a high safety.
孙诗琦, 朴倩. 谷氨酰胺联合促红细胞生成素治疗坏死性小肠结肠炎早产儿的临床疗效及对患儿血清IL-6 TNF-α和i-FABP水平的影响[J]. 河北医学, 2024, 30(4): 682-687.
SUN Shiqi, PIAO Qian. Clinical Efficacy of Glutamine Combined with Erythropoietin in the Treatment of Necrotizing Enterocolitis in Premature Infants and Its Effect on Serum IL-6 TNF-α and i-FABP Levels. HeBei Med, 2024, 30(4): 682-687.
2024, Vol. 30 
冀公网安备13080202000677号