超声“四切面”法联合妊娠中期产妇血清Freeβ-hCG和uE3筛查胎儿严重先天性心脏病的研究

doi:10.3969/j.issn.1006-6233.2024.04.026

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1217 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要 目的: 探究超声“四切面”法联合妊娠中期孕妇血清游离人绒毛膜促性腺激素(Freeβ-hCG)和雌三醇(uE3)筛查胎儿严重先天性心脏病(CHD)的临床应用价值。方法: 选择2020年1月到2021年6月我院行妊娠中期CHD筛查的孕妇97例,检测孕妇血清Freeβ-hCG和uE3水平,采用超声“四切面”法筛查CHD,分析超声“四切面”法联合血清Freeβ-hCG和uE3水平对CHD的诊断价值。结果: 97例孕妇随访确诊为严重CHD 9例(9/97,9.28%);超声“四切面”法检查提示高危胎儿25例,其中4例确诊为严重CHD(4/25,16.00%);孕妇血清学检测提示高危胎儿36例,其中6例最终确诊为严重CHD(6/36,16.67%);超声“四切面”法联合孕妇血清学检测提示高危胎儿9例,其中5例确诊为严重CHD(5/9,55.56%)。超声“四切面”法筛查严重CHD的敏感度、特异度、准确度、阳性预测值和阴性预测值分别为16.00%、93.51%、74.51%、44.44%和77.22%。孕妇血清Freeβ-hCG和uE3水平筛查严重CHD的敏感度、特异度、准确度、阳性预测值和阴性预测值分别为55.56%、95.31%、92.08%、66.67%和64.00%,;二者联合筛查严重CHD的敏感度、特异度、准确度、阳性预测值和阴性预测值分别为55.56%、95.65%、92.08%、55.56%和91.09%。二者联合检测的诊断情况高于单一检测方法(P<0.05)。结论: 超声“四切面”法对妊娠中期孕妇筛查严重CHD具有较高的诊断价值,联合孕妇血清Freeβ-hCG和uE3水平能进一步提高诊断准确度,具有较好的临床应用价值。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章

关键词 ：超声, “四切面”法, 人绒毛膜促性腺激素, 雌三醇, 先天性心脏病

Abstract：Objective: To investigate the clinical application value of the "four-plane" method of ultrasound combined with mid-pregnancy maternal serum free human chorionic gonadotropin (Freeβ-hCG) and estriol (uE3) for screening severe congenital heart disease (CHD) in fetuses. Methods: A total of 97 pregnant women who underwent mid-pregnancy CHD screening in our hospital from January 2020 to June 2021 were selected. The maternal serum Freeβ-hCG and uE3 levels were detected, and the "four-plane" method of ultrasound was used to screen for CHD. The diagnostic value of the "four-plane" method of ultrasound combined with serum Freeβ-hCG and uE3 levels for CHD was analyzed. Results: A total of 9 cases (9/97, 9.28%) of severe CHD were confirmed by follow-up; 25 cases of high-risk fetuses were detected by the "four-plane" method of ultrasound, of which 4 cases were confirmed to have severe CHD (4/25, 16.00%); 36 cases of high-risk fetuses were detected by maternal serum biochemical test, of which 6 cases were finally confirmed to have severe CHD (6/36, 16.67%); and 9 cases of high-risk fetuses were detected by the combined "four-plane" method of ultrasound and maternal serum biochemical test, of which 5 cases were confirmed to have severe CHD (5/9, 55.56%). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the "four-plane" method of ultrasound for screening severe CHD were 16.00%, 93.51%, 74.51%, 44.44%, and 77.22%, respectively. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of maternal serum Freeβ-hCG and uE3 levels for screening severe CHD were 55.56%, 95.31%, 92.08%, 66.67%, and 64.00%, respectively. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the combined screening for severe CHD were 55.56%, 95.65%, 92.08%, 55.56%, and 91.09%, respectively. The diagnostic results of the combined detection were higher than those of the single detection method (P<0.05). Conclusion: The "four-plane" method of ultrasound has a high diagnostic value for screening severe CHD in pregnant women in mid-pregnancy. The combination of maternal serum Freeβ-hCG and uE3 levels can further improve the diagnostic accuracy and has good clinical application value.

Key words： Ultrasound "Four-plane" method Human chorionic gonadotropin Estriol Congenital heart disease

基金资助:河北省卫生健康委医学科学研究课题,(编号:20231369);承德市科技计划项目,(编号:202204A052)

通讯作者: 吴文瑛

引用本文:

李博, 张欢欢, 曲东辉, 王锟, 刘天鑫, 吴文瑛. 超声“四切面”法联合妊娠中期产妇血清Freeβ-hCG和uE3筛查胎儿严重先天性心脏病的研究[J]. 河北医学, 2024, 30(4): 665-669.
LI Bo, ZHANG Huanhuan, QU Donghui, et al. A Study on the Value of Combined Mid-Pregnancy Serum Freeβ-hCG and uE3 Screening for Severe Congenital Heart Disease in Pregnant Women Using the "Four-Plane" Method of Ultrasound. HeBei Med, 2024, 30(4): 665-669.

链接本文:

http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2024.04.026 或 http://www.hbyxzzs.cn/CN/Y2024/V30/I4/665