癫痫患者脑电图异常和血清BDNF GFAP miR-7-5p表达特征及与认知功能的关系

doi:10.3969/j.issn.1006-6233.2024.04.018

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (1472 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要 目的: 探究癫痫患者脑电图异常和BDNF、GFAP、miR-7-5p表达特征,并探究各指标与患者认知功能的关系。方法: 本研究以我院2017年4月至2021年4月期间治疗的294例癫痫患者为对象,采用MoCA评分对患者的认知功能进行评价,并据此对患者进行分组:将得分≥26分的198例患者纳入认知正常组,得分<26分的96例患者纳入认知障碍组,患者均接受脑电图检查、血清BDNF、GFAP、miR-7-5p检测,比较组间脑电图检查异常情况及血清BDNF、GFAP、miR-7-5p表达差异,并探究上述指标与认知障碍的关联。结果: 对两组患者的MoCA评分进行分析可知认知障碍组患者的MoCA各项评分均低于认知正常组(P<0.05)。与认知正常组患者相比,认知障碍组患者脑电图无异常占比降低,认知障碍组患者脑电图痫样放电、脑电图慢波发放的发生率高于认知正常组(P<0.05)。与认知正常组患者相比较,认知障碍组BDNF、miR-7-5p降低,GFAP升高(P<0.05)。通过Pearson相关性分析发现,患者的MoCA评分与血清中的BDNF和miR-7-5p表达呈正相关,与其GFAP表达呈负相关(P<0.05)。经ROC曲线分析,血清BDNF、miR-7-5p及GFAP表达对癫痫患者认知障碍的发生具有一定诊断价值,其AUC值分别为0.836、0.845、0.957。结论: 伴有认知障碍的癫痫患者脑电图异常特征以脑电图痫样放电、脑电图慢波发放为主,血清BDNF、miR-7-5p表达低于认知正常的癫痫患者,GFAP表达高于认知正常的癫痫患者,且血清BDNF、miR-7-5p及GFAP表达对癫痫患者认知障碍的发生具有一定诊断价值。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	白杨
	杨越
	齐会珍

关键词 ：癫痫, 脑电图异常, 认知障碍, 脑源性神经营养因子, 胶质纤维酸性蛋白, miR-7-5p

Abstract：Objective: To explore the relationship between EEG abnormalities, serum levels of Brain-Derived Neurotrophic Factor (BDNF), Glial Fibrillary Acidic Protein (GFAP), and miR-7-5p expression characteristics, and cognitive function in epilepsy patients. Methods: The study included 294 epilepsy patients treated at our hospital from April 2017 to April 2021. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) scale. Patients were divided into two groups based on their MoCA scores: 198 patients with scores ≥26 were included in the cognitively normal group, while 96 patients with scores <26 were included in the cognitive impairment group. All patients underwent EEG examinations. The study compared EEG abnormalities and serum levels of BDNF, GFAP, and miR-7-5p between the groups and investigated their association with cognitive impairment. Results: Analysis of the MoCA scores showed that patients in the cognitive impairment group had significantly lower scores than those in the cognitively normal group (P<0.05). Compared to the cognitively normal group, patients in the cognitive impairment group had a lower proportion of normal EEGs and higher rates of epileptiform discharges and slow-wave activity (P<0.05). Serum levels of BDNF and miR-7-5p were lower, while GFAP levels were higher in the cognitive impairment group (P<0.05). Pearson correlation analysis indicated that cognitive function in epilepsy patients was positively correlated with BDNF and miR-7-5p levels and negatively correlated with GFAP levels (P<0.05). ROC curve analysis demonstrated that BDNF, miR-7-5p, and GFAP levels have diagnostic value for cognitive impairment in epilepsy patients, with AUC values of 0.836, 0.845, and 0.957, respectively. Conclusion: The abnormal characteristics of EEG in patients with cognitive impairment are mainly EEG discharge and slow wave distribution of EEG. The expression of serum BDNF and miR-7-5p is lower than that of patients with normal epilepsy, and the expression of GFAP is higher than that of patients with normal epilepsy, and serum BDNF, miR-7-5p and GFAP have certain diagnostic value for the occurrence of cognitive impairment in patients with epilepsy.

Key words： Epilepsy EEG abnormalities Cognitive impairment Brain-derived neurotrophic factor Glial fibrillary acidic protein miR-7-5p

基金资助:新疆维吾尔自治区自然科学基金资助项目,(编号:2023D01C246)

引用本文:

白杨, 杨越, 齐会珍. 癫痫患者脑电图异常和血清BDNF GFAP miR-7-5p表达特征及与认知功能的关系[J]. 河北医学, 2024, 30(4): 623-629.
BAI Yang, YANG Yue, QI Huizhen. The Relationship Between EEG Abnormalities and Serum BDNF GFAP miR-7-5p Expression Characteristics and Cognitive Function in Epilepsy Patients. HeBei Med, 2024, 30(4): 623-629.

链接本文:

http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2024.04.018 或 http://www.hbyxzzs.cn/CN/Y2024/V30/I4/623

[1] Beghi E.The Epidemiology of epilepsy[J].Neuroepidemiology,2020,54(2):185-191.
[2] Katyayan A,Diaz-Medina G.Epilepsy:epileptic syndromes and treatment[J].Neurol Clin,2021,39(3):779-795.
[3] Benbadis SR,Beniczky S,Bertram E,et al.The role of EEG in patients with suspected epilepsy[J].Epileptic Disord,2020,22(2):143-155.
[4] 王满利,章晓富,樊玉香,等.癫痫患者血清长链非编码RNA母系表达基因3、miR-7-5p表达与认知功能的关系[J].中国卫生检验杂志,2022,32(24):2998-3002.
[5] Zhao J,Wang B.MiR-7-5p enhances cerebral ischemia-reperfusion injury by degrading sirt1 mRNA[J].Cardiovasc Pharmacol,2020,76(2):227-236.
[6] Pinto TCC,Machado L,Bulgacov TM,et al.Is the montreal cognitive assessment (MoCA) screening superior to the Mini-Mental State Examination (MMSE) in the detection of mild cognitive impairment (MCI) and Alzheimer's Disease (AD) in the elderly?[J] Int Psychogeriatr,2019,31(4):491-504.
[7] Pinto LF,Adda CC,Silva LC,et al.Contralateral interictal and ictal EEG epileptiform activity accentuate memory impairment in unilateral mesial temporal sclerosis patients[J].Neuropsychology,2017,31(3):268-276.
[8] Babiloni C,Del Percio C,Lizio R,et al.Cortical sources of resting state electroencephalographic alpha rhythms deteriorate across time in subjects with amnesic mild cognitive impairment[J].Neurobiol Aging,2014,35(1):130-142.
[9] 李陶乐,许虹.运用事件相关电位评价颞叶癫痫患者认知功能及其与头颅磁共振和脑电图异常的相关性分析[J].中华医学杂志,2019,99(27):2115-2118.
[10] 姚晓娟,陈旨娟,毓青,等.脑电图-功能磁共振成像技术对局灶性癫痫致痫灶定位的价值[J].中华医学杂志,2015,95(13):987-990.
[11] 朱慧,肖正军,高茂军.癫痫患者事件相关电位P300及影响因素研究[J].中国实用神经疾病杂志,2016(3):14-15.
[12] 闻红斌.血清BDNF、IGF-1及Hcy与癫痫患者认知功能损害关系研究[J].基因组学与应用生物学,2018,37(10):4547-4552.
[13] Xu H,Nie B,Liu L,et al.Curcumin prevents brain damage and cognitive dysfunction during ischemic-reperfusion through the regulation of miR-7-5p[J].Curr Neurovasc Res,2019,16(5):441-454.
[14] Li X,Li G,Jin Y,et al.Long non-coding RNA maternally expressed 3 (MEG3) regulates isoflurane-induced cognitive dysfunction by targeting miR-7-5p[J].Toxicol Mech Methods,2022,32(6):453-462.