Abstract：Objective: To explore the correlation between serum chitinase 3-like protein 1 (Chi3L1), free fatty acids (NEFAs), glycolipid metabolism, and bone density in patients with type 2 diabetes mellitus (T2DM) complicated by osteoporosis.Methods: A total of 110 T2DM patients admitted to our hospital from January 2020 to April 2023 were selected for the study. Based on the presence of osteoporosis, T2DM patients were divided into the osteoporosis group (38 cases) and non-osteoporosis group (72 cases). Clinical data of T2DM patients were collected. Results: In the osteoporosis group, Chi3L1 levels were significantly lower, while NEFAs levels were significantly higher than those in the non-osteoporosis group (P<0.001). Glycated hemoglobin (HbA1c) and homeostasis model assessment of insulin resistance (HOMA-IR) were significantly higher in the osteoporosis group compared to the non-osteoporosis group (P<0.05). Bone density was significantly lower in the osteoporosis group (P<0.05). Serum Chi3L1 levels were negatively correlated with HbA1c and HOMA-IR, and positively correlated with bone density (P<0.05). NEFAs levels were positively correlated with HbA1c and HOMA-IR, and negatively correlated with bone density (P<0.05). Compared to the non-osteoporosis group, the osteoporosis group had a higher proportion of T2DM patients with low grip strength (P<0.05). Both NEFAs and Chi3L1 were influencing factors for the occurrence of osteoporosis in T2DM patients (P<0.05). Conclusion: Decreased serum Chi3L1 levels and increased NEFAs levels are associated with the occurrence of osteoporosis in T2DM patients and are significantly correlated with glycolipid metabolism and bone density.
朱瑞, 马洪川, 陈华玲, 杨进红. 2型糖尿病合并骨质疏松症患者血清Chi3L1 NEFAs 与糖脂代谢及骨密度的相关性[J]. 河北医学, 2024, 30(3): 448-452.
ZHU Rui, MA Hongchuan, CHEN Hualing, et al. Correlation of Serum Chi3L1 NEFAs with Glycolipid Metabolism and Bone Density in Patients with Type 2 Diabetes Mellitus Complicated by Osteoporosis. HeBei Med, 2024, 30(3): 448-452.
[1] 谭波,胡豇,卢冰,等.CTRP3在老年2型糖尿病合并骨质疏松患者血清中的表达及其与骨折风险的关系[J].中国老年学杂志,2023,43(9):2107-2110. [2] 田慧.老年女性糖尿病和骨质疏松症的防治策略[J].中华保健医学杂志,2019,21(6):493-495. [3] Park KR,Park JI,Lee S,et al.Chi3L1 is a therapeutic target in bone metabolism and a potential clinical marker in patients with osteoporosis[J].Pharmacol Res,2022,184(9):106-113. [4] Hierons SJ,Marsh JS,Wu D,et al.The interplay between non-esterified fatty acids and plasma zinc and its influence on thrombotic risk in obesity and type 2 diabetes[J].Int Mol Sci,2021,22(18):101-114. [5] Barzilay JI,Buzkova P,Djoussé L,et al.Serum non-esterified fatty acid levels and hip fracture risk:the cardiovascular health study[J].Osteoporos Int,2021,32(9):1745-1751. [6] 朱大龙,陆菊明.《中国2型糖尿病防治指南(2020年版)》编写说明[J].中华糖尿病杂志,2021,13(4):312-314. [7] 中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊疗指南(2022)[J].中国全科医学,2023,26(14):1671-1691. [8] Di Rosa M,Malaguarnera L.Chitinase 3 like-1:an emerging molecule involved in diabetes and diabetic complications[J].Pathobiology,2016,83(5):228-242. [9] JGravallese EM,Manning C,Tsay A,et al.Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor[J].Arthritis Rheum,2000,43(2):250-258. [10] Lee DW,Kwon JY,Kim HK,et al.Propofol attenuates osteoclastogenesis by lowering RANKL/OPG ratio in mouse osteoblasts[J].Int Med Sci,2018,15(7):723-729. [11] 王兴慧,朱艺玮,李伟,等.高浓度NEFAs血症通过抑制PGC-1α引起奶牛肝细胞脂质蓄积[J].吉林农业大学学报,2023,45(1):116-120. [12] Kimura I,Ichimura A,Ohue-Kitano R,et al.Free fatty acid receptors in health and disease[J].Physiol Rev,2020,100(1):171-210.
2024, Vol. 30 
冀公网安备13080202000677号