Abstract：Objective: To investigate the predictive value of serum human apoptosis-associated speck-like protein (ASC) and NOD-like receptor heat protein structural domain-related protein 3 (NLRP3) in rheumatoid arthritis (RA) patients. Methods: A total of 88 patients with RA diagnosed at our hospital from November 2021 to June 2023 were enrolled as the RA group, and 88 healthy volunteers were enrolled as the control group. Serum ASC and NLRP3 levels were measured by enzyme-linked immunosorbent assay. Spearman correlation analysis was used to analyze the correlation between serum ASC, NLRP3 levels and DAS28 scores in patients with RA, and logistic regression analysis was used to analyze the influencing factors of RA. Results: The serum ASC levels in the RA group were significantly higher than those in the healthy control group , and the NLRP3 levels were significantly higher than those in the healthy control group , with statistical significance (P<0.05). Logistic regression analysis showed that ASC and NLRP3 were independent risk factors for RA patients (P<0.05). Conclusion: The increased serum ASC and NLRP3 levels are independently correlated with DAS28 scores, suggesting that serum ASC and NLRP3 have potential diagnostic value for RA and its disease activity.
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2024, Vol. 30 
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