Abstract：Objective: To investigate the expression of calcitonin STC2 in cervical cancer tissue and evaluate its clinical significance. Methods: A retrospective study was conducted on cervical cancer patients (n=88) from Dongguan People's Hospital from January 2022to May 2022. Immunohistochemical method was used to determine the expression of STC2 in cervical tissue of patients. Real time fluorescence quantitative PCR was used to detect the gray value of STC2. compare the grayscale values of STC2 mRNA between cervical cancer tissue and normal tissue, analyze the expression of STC2 in different clinical characteristics of cervical cancer, and perform logistic regression analysis on their correlation. Results: The grayscale values of STC2 mRNA in cervical cancer tissues were higher than those in adjacent tissues, with statistical significance (P<0.05); The positive expression of STC2 in cervical cancer tissue showed statistically significant differences in different infiltration depths, differentiation levels, lymph node metastasis, and TNM staging, P<0.05; Multivariate logistic regression analysis showed that depth of infiltration, degree of differentiation, lymph node metastasis, and TNM staging were independent influencing factors for STC2 positivity; The 5-year Overall survival(OS) and Progression-Free Survival(PFS) of the STC2 positive group were lower than those of the STC2 negative group, with a statistically significant difference (P<0.05); Pearson analysis showed that the expression of STC2 was negatively correlated with OS and PFS (r=-0.747, -0.683, P<0.05). Conclusion: STC2 has a high expression in cervical cancer tissues, which has nothing to do with age, tumor diameter, pathological classification, depth of invasion, degree of differentiation and TNM stage, but is related to lymph node metastasis, which should be paid greatattention to.
邓润叨, 付霞霏. 斯钙素2在宫颈癌组织中的表达及临床意义[J]. 河北医学, 2024, 30(2): 255-259.
DENG Rundao, FU Xiafei. Expression and Clinical Significance of Stanniocalcin 2 (STC2) in Cervical Cancer Tissues. HeBei Med, 2024, 30(2): 255-259.
2024, Vol. 30 
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