Relationship between Hcy ApoB/ApoAⅠand Ambulatory Arterial Stiffness Index and Carotid Plaque Properties in Elderly Patients with Acute Cerebral Infarction
WANG Guozhen, HAO Jinglan, ZHANG Chenggang
Chuzhou First People's Hospital, Anhui Chuzhou 239000, China
Abstract：Objective: To observe the relationship between changes of homocysteine (Hcy), apolipoprotein B (ApoB)/apolipoprotein AⅠ(ApoAⅠ) and ambulatory arterial stiffness index (AASI) and carotid plaque properties in elderly patients with acute cerebral infarction (ACI).Methods: A total of 103 elderly patients with ACI (61 cases of stable plaque and 42 cases of unstable plaque) admitted to hospital from July 2021 to July 2023 were included. The Hcy, ApoB/ApoAⅠand AASI were observed. The relationship between Hcy, ApoB, ApoAⅠ, AASI and carotid plaque properties was analyzed by univariate analysis and multivariate Logistic regression analysis, and receiver operating characteristic curve (ROC) was plotted to analyze the evaluated efficiency of the three indicators on carotid plaque properties.Results: The Hcy, ApoB/ApoAⅠ, AASI and carotid intima-media thickness (IMT) in unstable plaque group were significantly higher than those in stable plaque group (P<0.05). Pearson correlation showed that Hcy, ApoB/ApoAⅠand AASI were positively correlated with IMT, showing statistical significance (r=0.354, 0.372, 0.390, P<0.05). Univariate analysis suggested that hypertension, diabetes mellitus and hyperlipidemia were related to the carotid plaque properties (P<0.05). Multivariate Logistic regression analysis revealed that hypertension, diabetes mellitus, hyperlipidemia, Hcy, ApoB/ApoAⅠ, and AASI were risk factors affecting the carotid plaque properties (P<0.05). ROC analysis showed that the AUCs of Hcy, ApoB/ApoAⅠ and AASI in evaluating the carotid plaque properties were 0.696, 0.711 and 0.764 respectively. The AUC of the combined evaluation of the three indicators was the highest (0.853), and the sensitivity and specificity under the maximum Youden index were 0.952 and 0.607 respectively.Conclusion: The changes of Hcy, ApoB/ApoAⅠ and AASI in elderly patients with ACI are related to the carotid plaque properties, and have certain evaluated value on unstable plaque.
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2024, Vol. 30 
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