Abstract：Objective: To analyze the level of peripheral blood immune spectrum in patients with bronchiectasis complicated with nontuberculous Mycobacterium (NTM). Methods: Ninety-six patients with bronchiectasis admitted to our hospital from May 2021 to May 2023 were selected. The patients were divided into an infection group (33 cases) and a non-infection group (63 cases) based on whether NTM infection was present. In the infection group, patients were further categorized based on the number of lung lobes affected by bronchiectasis: 1~2 lobes group (11 cases), 3~4 lobes group (12 cases), and 5~6 lobes group (10 cases). Peripheral blood levels of immunoglobulins, T lymphocyte subsets, high-sensitivity C-reactive protein (hs-CRP), cystatin C (CysC), and homocysteine (Hcy) were compared between the groups. Results: There was no significant difference in the levels of peripheral blood immunoglobulins between the two groups (P>0.05). The peripheral blood CD3+ and CD4+ levels were lower, and CD8+ levels were higher in the infection group compared to the non-infection group (P<0.05). There was no significant difference in peripheral blood Hcy levels between the two groups (P>0.05). However, hs-CRP and CysC levels were higher in the infection group than in the non-infection group (P<0.05). When comparing different groups based on the number of affected lung lobes, there was no significant difference in peripheral blood IgA, IgM, IgG, CD8+ levels (P>0.05). However, the CD3+ and CD4+ levels showed a decreasing trend from the 1~2 lobes group to the 5~6 lobes group (P<0.05). There was no significant difference in peripheral blood hs-CRP, CysC, and Hcy levels among the three groups (P>0.05). Conclusion: In patients with bronchiectasis complicated by NTM infection, peripheral blood CD3+ and CD4+ levels are decreased, CD8+, hs-CRP, and CysC levels are increased. Furthermore, CD3+ and CD4+ levels are correlated with the number of affected lung lobes.
梅益枝, 姚超, 张毕玲. 支气管扩张合并NTM病患者外周血免疫指标谱水平分析[J]. 河北医学, 2024, 30(1): 98-102.
MEI Yizhi, YAO Chao, ZHANG Biling. Analysis of Peripheral Blood Immune Indices in Patients with Bronchiectasis Complicated by NTM Infection. HeBei Med, 2024, 30(1): 98-102.
2024, Vol. 30 
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