Abstract：Objective: To explore the effects of continuous blood purification (CBP) and intermittent hemodialysis (IHD) on levels of serum retinol-binding protein 4 (RBP4), transferrin (Tf) and β2-microglobulin (β2-MG) in elderly patients with acute renal failure (ARF). Methods: A total of 114 ARF patients admitted to our hospital from January 2021 to January 2023 were included in this study. The patients were randomly divided into two groups using a random number table, with 57 cases in each group (observation group and control group). The control group received IHD, and the observation group received CBP, with a dialysis period of 2 weeks for both groups. Clinical efficacy, serum levels [RBP4, Tf, β2-MG, Serum Creatinine (Scr), and Blood Urea Nitrogen (BUN)] before and 2 weeks after dialysis, as well as electrolyte indicators (K+, Cl-, Na+), were compared between the two groups. Complications during the treatment were recorded. Results: After dialysis, the total effective rates in the observation group and control group were 94.74% (54/57) and 78.95% (45/57), respectively, with a statistically significant difference (P<0.05). After 2 weeks of dialysis, the serum levels of RBP4, Tf, β2-MG, Scr, and BUN in both groups decreased significantly compared to before dialysis, and the reduction in the observation group was greater than that in the control group (P<0.05). After 2 weeks of dialysis, the serum levels of K+, Cl-, and Na+ in both groups increased significantly compared to before dialysis, and the increase in the observation group was greater than that in the control group (P<0.05). The incidence of complications during dialysis in both groups (5.26%, 7.02%) showed no significant difference (P>0.05). Conclusion: CBP is more effective in elderly ARF patients, effectively removing small and large molecular toxins from the blood and maintaining electrolyte stability.
2024, Vol. 30 
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