Abstract：Objective: To explore the diagnostic value of blood viscosity, reticulated platelets, and platelet parameters in elderly patients with immune thrombocytopenia (ITP). Methods: A total of 82 elderly (age 60 and above) ITP patients from our hospital between 2020 and 2022 were included as the observation group. The control group included 50 elderly patients with non-immune thrombocytopenia (NITP) (25 cases with cirrhosis, 15 cases with hematological diseases, and 10 cases with other tumors). Another 50 elderly health examination participants were included as the second control group. Blood samples were collected for blood rheology analysis, including blood viscosity using a hemorheology analyzer, and platelet parameters [platelet distribution width (PDW), mean platelet volume (MPV), platelet-large cell ratio (P-LCR)] using an automated hematology analyzer. Comparative analysis of blood viscosity, reticulated platelets, PDW, MPV, and P-LCR before and after treatment was performed. Results: Before treatment, the observation group showed higher PDW, MPV, and reticulated platelet ratio compared to both control groups, while blood viscosity was lower, with statistical significance (P<0.05). There was no significant difference between Control Group 1 and Control Group 2 (P>0.05). As the platelet count decreased in the observation group, PDW and MPV increased, and blood viscosity decreased, showing statistically significant differences between the observation group and the control groups (P<0.05). Comparative analysis before and after treatment showed that in the observation group, the blood viscosity and platelet count of severe and mild-to-moderate patients increased after treatment (P<0.05), while reticulated platelets, P-LCR, PDW, and MPV significantly decreased and were lower than before treatment, with statistical significance (P<0.05). Conclusion: Determining blood viscosity, reticulated platelets, and platelet parameters significantly contributes to the etiological diagnosis and disease assessment of elderly ITP patients. Additionally, it plays a positive role in prognosis evaluation, providing ample diagnostic support for clinical practice.
2024, Vol. 30 
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