[1] Lane CA,Hardy J,Schott JM.Alzheimer's disease[J].European journal of neurology,2018,25(1):59-70. [2] Xuan W,Xie W,Li F,et al.Dualistic roles and mechanistic insights of macrophage migration inhibitory factor in brain injury and neurodegenerative diseases[J].Journal of cerebral blood flow metabolism,2023,43(3):341-56. [3] Liang CJ,Li JH,Zhang Z,et al.Suppression of MIF-induced neuronal apoptosis may underlie the therapeutic effects of effective components of Fufang Danshen in the treatment of Alzheimer's disease[J].Acta pharmacologica Sinica,2018,39(9):1421-1438. [4] Bacher M,Deuster O,Aljabari B,et al.The role of macrophage migration inhibitory factor in Alzheimer's disease[J].Molecular medicine,2010,(16):116-121. [5] Oyama R,Yamamoto H,Titani K.Glutamine synthetase,hemoglobin alpha-chain,and macrophage migration inhibitory factor binding to amyloid beta-protein:their identification in rat brain by a novel affinity chromatography and in Alzheimer's disease brain by immunoprecipitation[J].Biochimica et biophysica acta,2000,(1479):91-102. [6] Zhang S,Zhao J,Zhang Y,et al.Upregulation of MIF as a defense mechanism and a biomarker of Alzheimer's disease[J].Alzheimer's research therapy,2019,11(1):54. [7] Hu J,Lin SL,Schachner M.A fragment of cell adhesion molecule L1 reduces amyloid-β plaques in a mouse model of Alzheimer's disease[J].Cell death disease,2022,13(1):48. [8] Carlred L,Michno W,Kaya I,et al.Probing amyloid-β pathology in transgenic Alzheimer's disease (tgArcSwe) mice using MALDI imaging mass spectrometry[J].Journal of neurochemistry,2016,138(3):469-478. [9] 李思苹,李文惠,孙安阳.阿尔茨海默病的tau蛋白病理传播机制与调节[J].中国病理生理杂志,2019,35(3):571-576. [10] Oikonomidi A,Tautvydait D,Gholamrezaee MM,et al.Macrophage migration inhibitory factor is associated with biomarkers of Alzheimer's disease pathology and predicts cognitive decline in mild cognitive impairment and mild dementia[J].Journal of Alzheimer's disease,2017,60(1):273-281. [11] Li SQ,Yu Y,Han JZ,et al.Deficiency of macrophage migration inhibitory factor attenuates tau hyperphosphorylation in mouse models of Alzheimer's disease[J].Journal of neuroinflammation,2015,(12):177. [12] Brosseron F,Kolbe CC,Santarelli F,et al.Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study[J].Alzheimer's dementia,2020,16(2):292-304. [13] Chen X,Chen Y,Qi D,et al.Multifaceted interconnections between macrophage migration inhibitory factor and psychiatric disorders[J].Progress in neuro-psychopharmacology biological psychiatry,2022,(1112):110422. [14] Nasiri E,Sankowski R,Dietrich H,et al.Key role of MIF-related neuroinflammation in neurodegeneration and cognitive impairment in Alzheimer's disease[J].Molecular medicine,2020,26(1):34. [15] Janoutova J,Machaczka O,Zatloukalová A,et al.Is Alzheimer's disease a type 3 diabetes A review[J].Central European journal of public health,2022,30(3):139-143. [16] Kassaar O,Pereira Morais M,Xu S,et al.Macrophage migration inhibitory factor is subjected to glucose modification and oxidation in Alzheimer's disease[J].Scientific reports,2017,(7):42874. [17] Vratari M,enk V,Bursa B,et al.Fructose diet ameliorate effects of macrophage migration inhibitory factor deficiency on prefrontal cortex inflammation,neural plasticity,and behavior in male mice[J].BioFactors,2023,49(1):90-107. [18] Fex Svenningsen ,Lring S,Srensen AL,et al.Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1[J].Cellular molecular life sciences,2017,74(24):4561-4572.