Clinical Characteristics and Clinical Significance of Changes in NT-proBNP and Echocardiographic Parameters in Elderly with Ejection Fraction Preserved Heart Failure Combined with Debility
LV Qiu, QIU Qingyong, DU Lanxue, et al
The 928th Hospital of the Joint Service Support Department of the Chinese People's Liberation Army, Hainan Haikou 570100, China
Abstract：Objective: To analyze characteristics in elderly patients with heart failure with preserved ejection fraction (HFpEF) and frailty, and to explore the clinical significance of peripheral blood N-terminal pro-B-type natriuretic peptide (NT-proBNP) and echocardiogram parameters. Methods: A total of 96 patients with HFpEF admitted to the hospital were enrolled between February 2021 and February 2023. The frailty was evaluated by Fried Frailty Evaluation Criteria within 24h after admission. According to the evaluation results, patients were divided into frailty group (n=56) and non-frailty group (n=40). The clinical data in the two groups were collected. The risk factors of frailty were analyzed by univariate analysis and multivariate Logsitic regression analysis. Results: Compared with non-frailty group, the age, proportion of NYHA grading at grade III/IV, proportion of nutritional risk and NT-proBNP level in frailty group were higher (P<0.05), while levels of hemoglobin (Hb) and albumin (ALB) were lower (P<0.05). The left ventricular ejection fraction (LVEF) in frailty group was lower (P<0.05), while left ventricular end-diastolic diameter (LVDD), left ventricular end-systolic diameter (LVDS) aortic diameter (AOD) were longer or larger (P<0.05). There was no significant difference in left atrial diameter (LVDS) or left ventricular posterior wall thickness (LVPW) between the two groups (P>0.05). Multivariate Logistic regression showed advanced age, NYHA grading at grade III/IV, high-level NT-proBNP and widened AOD were independent risk factors of frailty in elderly patients with HFpEF (P<0.05). Conclusion: Elderly patients with HFpEF have high incidence of frailty. Advanced age, NYHA grading at grade III/IV, high-level NT-proBNP, and widened AOD are independent risk factors of frailty.
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2023, Vol. 29 
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