BRAF基因突变型甲状腺癌患者血清TSH TgAb MK表达及临床意义

doi:10.3969/j.issn.1006-6233.2023.09.09

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摘要 目的: 探讨抗鼠科肉瘤病毒癌基因同源物B1(BRAF)基因突变型甲状腺癌(TC)患者血清促甲状腺激素(TSH)、甲状腺球蛋白抗体(TgAb)、中期因子(MK)水平,分析其对突变型TC的诊断价值。方法: 选取2021年1月至2022年1月本院收治的83例BRAF基因突变型TC患者作为突变组,遵循1∶1分配原则选取同期83例BRAF基因野生型TC患者作为野生组。统计两组人口学资料、临床病理特征、血清TSH、TgAb、MK水平。Logistic回归方程分析突变型TC影响因素。评价各指标对突变型TC的诊断价值,分析其对突变型TC危险度的影响。结果: 两组肿瘤分期、被膜侵犯、肿瘤数目、颈部淋巴结转移、中央区淋巴结转移及血清TSH、TgAb、MK水平比较差异具有统计学意义(P<0.05);血清TSH、TgAb、MK水平与BRAF基因突变呈正相关,差异具有统计学意义(P<0.05);血清TSH、TgAb、MK水平升高是BRAF基因突变型TC高危因素(P<0.05);血清TSH、TgAb、MK联合诊断BRAF基因突变型TC的AUC大于单一诊断效能,差异具有统计学意义(P<0.05);TSH、TgAb、MK高表达者发生BRAF基因突变TC危险度分别是低表达者的1.500、1.625、2.617倍,差异具有统计学意义(P<0.05)。结论: BRAF基因突变型TC患者血清TSH、TgAb、MK水平升高,联合检测其水平对BRAF基因突变型TC具有一定诊断价值。

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	刘培红
	安黎云
	邵茹彬
	陈芳

关键词 ：甲状腺癌, 抗鼠科肉瘤病毒癌基因同源物B1, 促甲状腺激素, 甲状腺球蛋白抗体, 中期因子

Abstract：Objective: To investigate the levels of serum thyrotropin (TSH), thyroglobulin antibody (TgAb) and intermediate factor (MK) in patients with thyroid cancer (TC) with the B1 (BRAF) gene homology of anti-mouse sarcoma virus, and to analyze the diagnostic value of TSH in patients with TC. Methods: 83 cases BRAF gene mutant TC patients admitted to our hospital from January 2021 to January 2022 were selected as the mutation group, and 83 cases BRAF gene wild-type TC patients in the same period were selected as the wild group following the principle of 1∶1 allocation. Demographic data, clinicopathological features, serum TSH, TgAb and MK levels of the two groups were analyzed. The influencing factors of mutant TC were analyzed by Logistic regression equation. The diagnostic value of each index on mutant TC was evaluated and its influence on the risk of mutant TC were analyzed. Results: There were significant differences in tumor stage, capsule invasion, tumor number, cervical lymph node metastasis, central lymph node metastasis and serum TSH, TgAb and MK levels between the two groups (P<0.05). Serum TSH, TgAb and MK levels were positively correlated with BRAF gene mutation (P<0.05). Increased serum TSH, TgAb and MK levels were the risk factors for BRAF mutant TC (P<0.05). The AUC of serum TSH, TgAb and MK in the diagnosis of BRAF mutant TC was greater than that of single diagnosis (P<0.05). The risk of BRAF gene mutation TC in high TSH, TgAb and MK expression group was 1.500, 1.625 and 2.617 times higher than that in low expression group (P<0.05). Conclusion: The serum levels of TSH, TgAb and MK in patients with BRAF mutant TC are elevated. The combined detection of TSH, TGAb and MK levels is of certain diagnostic value for BRAF mutant TC.

Key words： Thyroid cancer Anti-murine sarcoma virus oncogene homologue B1 Thyroid-stimulating hormone Thyroglobulin antibodies Intermediate factor

基金资助:河北省2021年度医学科学研究课题计划项目,(编号:20210780)

通讯作者: 安黎云, 邵茹彬, 陈芳

引用本文:

刘培红, 安黎云, 邵茹彬, 陈芳. BRAF基因突变型甲状腺癌患者血清TSH TgAb MK表达及临床意义[J]. 河北医学, 2023, 29(9): 1452-1458.
LIU Peihong, AN Liyun, SHAO Rubin, et al. Expression and Clinical Significance of Serum TSH TgAb and MK in Patients with BRAF Gene Mutant Thyroid Cancer. HeBei Med, 2023, 29(9): 1452-1458.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2023.09.09 或 http://www.hbyxzzs.cn/CN/Y2023/V29/I9/1452

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