Abstract：Objective: To analyze the changes of peripheral blood absolute lymphocyte count (ALC), serum C-reactive protein (CRP) and procalcitonin (PCT), and their relationship with disease severity in patients with chronic obstructive pulmonary disease (COPD). Methods: A total of 102 patients with COPD treated in the hospital were enrolled between January 2019 and February 2022. According to disease progression and the severity of pulmonary function, they were divided into stable COPD group and acute exacerbation of COPD (AECOPD) group, and grades I-IV groups. A total of 100 healthy controls were enrolled as control group. The differences in levels of ALC, CRP and PCT in different groups were detected and compared, and the correlation between the above indexes and pulmonary function index [forced expiratory volume in 1 second (FEV1) as a percentage of predicted value (FEV1%)] was analyzed. The changes of ALC, CRP and PCT before and after treatment were observed. Results: The peripheral blood ALC was significantly lower in COPD group than control group, while levels of CRP and PCT were significantly higher in COPD group (P<0.05). The peripheral blood ALC was significantly lower in AECOPD group than stable COPD group, while levels of CRP and PCT were significantly higher in AECOPD group (P<0.05). The differences in levels of ALC, CRP and PCT among patients with different severity of pulmonary function were statistically significant (P<0.05). Further pairwise comparison showed that ALC level in patients at grade IV was lower than that at grades I and II, while CRP and PCT levels were the highest in patients at grade IV, followed by grade III, grade II and grade I (P<0.05). The level of peripheral blood ALC was positively correlated with FEV1%, while CRP and PCT were negatively correlated with it (P<0.05). After treatment, ALC was significantly increased, while levels of CRP and PCT were significantly decreased (P<0.05). Conclusion: The levels of peripheral blood ALC, serum CRP and PCT are closely related to disease severity in COPD patients, which can also guide the treatment of AECOPD.
康恒, 李迅, 文华, 薛本洁. COPD患者外周血淋巴细胞计数及血清CRP PCT变化与疾病严重程度的关系[J]. 河北医学, 2023, 29(8): 1287-1292.
KANG Heng, LI Xun, WEN Hua, et al. Changes of Peripheral Blood Absolute Lymphocyte Count Serum CRP and PCT in Patients with COPD and Their Relationship with Disease Severity. HeBei Med, 2023, 29(8): 1287-1292.
2023, Vol. 29 
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