Abstract：Objective: To analyze the effect of cyclosporine on cholelithiasis in a population of patients with aplastic anemia. Methods: Two hundred and sixty-three patients with aplastic anemia admitted to our hospital from January 2016 to May 2022 were selected and divided into 103 cases in the anti-thymocyte globulin group (ATG group) and 160 cases in the cyclosporine group (CsA group) according to the immunosuppressive treatment regimen.Liver function and lipids were measured in peripheral blood laboratory after admission and after receiving 6 months of treatment,and cholestasis and stone formation in the biliary system were examined by color Doppler ultrasound in all patients. Results: The incidence of cholestasis in the ATG group was 5.83% and the incidence of stones was 2.91%; the incidence of cholestasis in the CsA group was significantly higher in the CsA group than in the ATG group (P<0.05,P<0.05); there was no significant difference in liver function between the two groups (P>0.05); the incidence of dyslipidemia was 2.91% in the ATG group and 9.38% in the CsA group during the same treatment cycle.The incidence of dyslipidemia in patients in the CsA group was significantly higher than that in the ATG group (P<0.05). Conclusion: Cholelithiasis can be secondary to the treatment of aplastic anemia with cyclosporine,among which gallbladder sediment stones are common,and the generation of stones may be closely related to cholestasis caused by cyclosporine,and CsA can cause dyslipidemia in patients.
吉桐莹, 李功辉, 王映芬. 环孢素对再生障碍性贫血患者胆石症形成的影响分析[J]. 河北医学, 2023, 29(7): 1217-1221.
JI Tongying, LI Gonghui, WANG Yingfen. Analysis of the Effect of Cyclosporine on Gallstone Formation in Patients with Aplastic Anemia. HeBei Med, 2023, 29(7): 1217-1221.
2023, Vol. 29 
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