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河北医学  2023, Vol. 29 Issue (6): 1043-1046    DOI: 10.3969/j.issn.1006-6233.2023.06.031
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来曲唑联合枸橼酸氯米芬对初治多囊卵巢综合征患者糖脂代谢及预后的影响
孙云霞, 饶阳阳, 刘伟
安徽省宣城市人民医院妇产科, 安徽 宣城 242000
Effect of Letrozole Combined with Clomiphene Citrate on Glycolipid Metabolism and Prognosis in Newly Treated Patients with Polycystic Ovary Syndrome
SUN Yunxia, RAO Yangyang, LIU Wei
Xuancheng People's Hospital, Anhui Xuancheng 242000, China
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摘要 目的: 探讨来曲唑(letrozole,LE)联合枸橼酸氯米芬(clomiphene citrate,CC)对初治多囊卵巢综合征(PCOS)患者糖脂代谢及预后。方法: 采用随机数字表将2021年1月至2022年6月期间安徽省宣城市人民医院收治的126例初治PCOS患者分为对照组(单用CC治疗,n=63)和观察组(LE联用CC治疗,n=63)。比较对照组与观察组治疗前后的糖脂代谢相关指标、性激素水平、排卵状况及不良反应。结果: 观察组患者治疗后的FPG、FINS、HOMA-IR、TG、TC、FSH、LH、E2、T均显著低于同期对照组,且这些指标治疗前后的变化水平均显著高于对照组,差异均有统计学意义(P<0.05)。观察组患者的成熟卵泡数目、成熟卵泡的直径均显著高于对照组,差异均有统计学意义(P<0.05)。观察组与对照组的不良反应的发生率比较,差异无统计学意义(P>0.05)。结论: LE联合CC能明显改善初治PCOS患者的糖脂代谢,促进卵巢排卵。
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孙云霞
饶阳阳
刘伟
关键词 多囊卵巢综合征来曲唑枸橼酸氯米芬糖脂代谢排卵预后    
AbstractObjective: To explore the effect of letrozole (LE) combined with clomiphene citrate (CC) on glycolipid metabolism and prognosis in newly treated patients with polycystic ovary syndrome (PCOS). Methods: A random number table was used to divide 126 newly diagnosed PCOS patients admitted to the People's Hospital of Xuancheng City, Anhui Province from January 2021 to June 2022 into a control group (treated with CC alone, n=63) and an observation group (treated with LE combined with CC, n=63). Glucose and lipid metabolism-related indicators, sex hormone levels, ovulation status and adverse effects was made between the control group and the observation group before and after treatment. Results: The FPG, FINS, HOMA-IR, TG, TC, FSH, LH, E2 and T of the patients in the observation group were all significantly lower than those of the control group after treatment, and the levels of changes in these indicators before and after treatment were all significantly higher than those of the control group, and the differences were all statistically significant (P<0.05). The number of mature follicles and the diameter of mature follicles in the observation group were significantly higher than those in the control group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05). Conclusion: LE combined with CC significantly improves glucolipid metabolism and promotes ovarian ovulation in patients with primary PCOS.
Key wordsPolycystic ovary syndrome    Letrozole    Clomiphene citrate    Glycolipid metabolism    Ovulation    Prognosis
    
基金资助:安徽省重点研究和开发计划项目,(编号:1804h08020267)
引用本文:   
孙云霞, 饶阳阳, 刘伟. 来曲唑联合枸橼酸氯米芬对初治多囊卵巢综合征患者糖脂代谢及预后的影响[J]. 河北医学, 2023, 29(6): 1043-1046.
SUN Yunxia, RAO Yangyang, LIU Wei. Effect of Letrozole Combined with Clomiphene Citrate on Glycolipid Metabolism and Prognosis in Newly Treated Patients with Polycystic Ovary Syndrome. HeBei Med, 2023, 29(6): 1043-1046.
链接本文:  
http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2023.06.031     或     http://www.hbyxzzs.cn/CN/Y2023/V29/I6/1043
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