Abstract：Objective: To investigate the predictive value of cardiac magnetic resonance signature tracking (CMR-FT) imaging for quantitative assessment of myocardial strain before and after treatment for dilated cardiomyopathy (DCM) on prognosis. Methods: Ninety-four patients with DCM admitted to our hospital from April 2018 to April 2021 were selected and given standard treatment according to guideline recommendations and followed up for 6 months, and divided into poor prognosis group (MACE occurred, 23 cases) and good prognosis group (no MACE occurred, 71 cases) according to whether major adverse cardiovascular events (MACE) occurred, and clinical data and cardiac function indexes before and after treatment were compared between the two groups [left ventricular ejection fraction (LVEF), amino-terminal brain natriuretic peptide precursor (NT-proBNP)], myocardial strain parameters [total strain (εs), passive strain (εe), active strain (εa), peak positive left ventricular systolic strain rate (SRs), peak negative left atrial strain rate in early left ventricular diastole (SRe), peak negative left atrial strain rate in late left ventricular diastole ( SRa)], to analyze the correlation between each myocardial strain parameter and cardiac function indexes, and to evaluate the prognostic impact and predictive value of the difference of each myocardial strain parameter before and after treatment. Results: LVEF before and after treatment was lower in the poor prognosis group than in the good prognosis group [(45.27±3.62)% versus (49.82±4.30)%, t=4.572, P<0.05, (48.96±4.15)% versus (56.41±5.03)%, t=6.423, P<0.05], and NT-proBNP was higher in the good prognosis group [( 1275.84±326.55) pg/mL versus (1014.79±259.87) pg/mL, t=3.924, P<0.05 and (1001.35±241.98) pg/mL versus (665.21±202.43) pg/mL, t=6.591, P<0.05]. The pre- and post-treatment εs, εe, εa, SRs, SRe, SRa and differences were smaller in the poor prognosis group than in the good prognosis group (all P<0.05); myocardial strain parameters were positively correlated with LVEF and negatively correlated with NT-proBNP before and after treatment (all P<0.05); logistic regression analysis showed that myocardial strain parameter differences all had a significant effect on prognosis (all P< Logistic regression analysis showed that the difference in myocardial strain parameters had a significant effect on prognosis (all P<0.05). Conclusion: The application of CMR-FT imaging for quantitative assessment of myocardial strain in patients with DCM has some predictive value for prognosis and provides a reference for the risk of poor prognosis in patients with DCM.
2023, Vol. 29 
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