Abstract：Objective: To observe the occurrence of acute kidney injury in patients with nephrotic syndrome and analyze the factors that may lead to the occurrence of acute kidney injury in patients, and to guide the development of clinical intervention countermeasures in order to reduce the risk of acute kidney injury. Methods: One hundred and twenty patients with nephrotic syndrome admitted to our hospital between January 2020 and January 2022 were included in the study, and the patients were divided into the occurrence group and the non-occurrence group based on the presence or absence of acute kidney injury, and the baseline data of the two groups were compared to analyze the factors that may lead to the occurrence of acute kidney injury in patients.Results: Among the 120 patients with nephrotic syndrome enrolled, 32 patients had acute kidney injury, including 15 patients of grade 1, 12 patients of grade 2, and 5 patients of grade 3; 88 patients did not have acute kidney injury; compared with the non-occurrence group, the occurrence group had higher age (≥60 years), use of low molecular dextrose (yes), co-infection (yes), irrational use of diuretics (yes), use of glucocorticoids (yes), creatinine ( ≥353.6 umol/L), and urea nitrogen (≥8.0 mmol/L) accounted for a higher proportion, and serum NGAL, IL-18, and neutrophil count were highly expressed (P<0.05); other data were compared between groups (P>0.05); the results of binomial logistic regression analysis showed that age (≥60 years), use of low-molecular dextro-anhydride (yes), co-infection (yes), irrational use of diuretics (yes), use of glucocorticoids (yes), creatinine (≥353.6 umol/L), and urea nitrogen (≥8.0 mmol/L) were all higher, and high expression of serum NGAL, IL-18, and neutrophil count were all influential factors in the development of acute kidney injury in patients with nephrotic syndrome (OR>1, P<0.05). Conclusion: Age, use of low molecular dextran, co-infection, irrational use of diuretics, use of glucocorticoids, creatinine, urea nitrogen, serum NGAL, IL-18, and neutrophil count are all important factors contributing to the increased risk of acute kidney injury in patients with nephrotic syndrome.
陈青苗, 陈岳尧, 周仕群, 陈意志. 肾病综合征患者并发急性肾损伤的现状及其因素分析[J]. 河北医学, 2023, 29(5): 776-782.
CHEN Qingmiao, CHEN Yueyao, ZHOU Shiqun, et al. Analysis of the Current Situation of Patients with Nephrotic Syndrome Complicated by Acute Kidney Injury and Its Factors. HeBei Med, 2023, 29(5): 776-782.
2023, Vol. 29 
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