Curative Effect of Budesonide Nebulization Combined with Ambroxol in the Treatment of Pediatric Bronchopneumonia and Its Effect on Serum CRP and PCT Levels
LIU Le, WANG Junxia, GAN Xinru, et al
General Hospital of Western Theater, Sichuan Chengdu 610000, China
Abstract：Objective: To investigate the curative effect of budesonide nebulization combined with ambroxol in the treatment of pediatric bronchopneumonia and its effect on serum CRP and PCT levels. Methods: A total of 186 children with bronchopneumonia treated in our hospital between June 2020 to September 2021 were enrolled and divided into observation group (n=93) and control group (n=93) by random number table method. The control group was treated with budesonide nebulization, while observation group was additionally treated with intravenous drip of ambroxol. The clinical curative effect after treatment, levels of inflammatory factors (CRP, PCT) and immune function (IgG, IgM, IgA) before and after treatment between the groups were compared. Results: After treatment, total response rate of observation group was higher than that of control group (93.55% vs 71.72%, P<0.05). After treatment, disappearance time of clinical symptoms was shorter in observation group than control group (P<0.05). After 5d of treatment, levels of CRP and PCT in both groups were decreased. The difference values of CRP and PCT before and after treatment in observation group were (25.93±4.54) mg/L and (1.03±0.25) μg/L, higher than those in control group [(16.15±3.72) mg/L, (0.84±0.19) μg/L, P<0.05]. After 5d of treatment, levels of IgA, IgM and IgG in both groups were increased. The difference values of IgA, IgM and IgG before and after treatment in observation group were (4.15±0.87) g/L, (0.46±0.13) g/L and (0.63±0.22) g/L, higher than those in control group [(1.67±0.39) g/L, (0.27±0.06) g/L, (0.27±0.08) g/L, P<0.05]. The incidence of adverse reactions between observation group and control group was similar the difference was not statistically significane [9.68% (9 cases) vs 7.53% (7 cases), P>0.05]. Conclusion: Compared with budesonide nebulization alone, curative effect of budesonide nebulization combined with ambroxol is better on children with bronchopneumonia, which can more effectively improve clinical symptoms, inflammatory factors and immune function, with certain safety.
刘乐, 王君霞, 甘新茹, 曾晓洁. 布地奈德雾化联合氨溴索治疗小儿支气管肺炎疗效及对血清CRP PCT水平的影响[J]. 河北医学, 2023, 29(4): 681-685.
LIU Le, WANG Junxia, GAN Xinru, et al. Curative Effect of Budesonide Nebulization Combined with Ambroxol in the Treatment of Pediatric Bronchopneumonia and Its Effect on Serum CRP and PCT Levels. HeBei Med, 2023, 29(4): 681-685.
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2023, Vol. 29 
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