Abstract：Objective: To analyze the relationship between 25 hydroxyvitamin D, microinflammation and fall in patients treated with hemodialysis. Methods: A total of 80 patients receiving maintenance hemodialysis (MHD) treatment in Chengde Central Hospital from January 2020 to June 2020 were divided into 25(OH)D low group and normal group according to their 25(OH)D level. Gender, age, dialysis age, height, weight, primary disease ,blood purification method of the patients and the occurrence of falls in the past one year were recorded. Blood procalcitonin (PCT), haemoglobin (Hb), blood albumin, blood calcium, blood phosphorus, parathyroid hormone, triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol and other indicators were tested. The relationship between 25(OH)D, PCT and fall was analyzed by Pearson correlation analysis,multiple linear regression and binary Logistic analysis. Results: The level of PCT, TG and TC in 25 (OH) D normal group were lower than those in 25 (OH) D low group, and the differences were statistically significant (P<0.05). The level of Hb in the 25 (OH) D normal group was higher than that in the 25(OH)D low group, and the difference was statistically significant (P<0.05). Pearson correlation analysis showed that there was a negative correlation between PCT,TC and 25(OH)D level. Multivariate regression analysis showed that PCT and TC were independent influencing factors of 25(OH)D level, and 25(OH)D level was an protective factor affecting fall in MHD patients. Conclusion: PCT plays an important role in the 25(OH)D level of MHD patients, it is an independent risk factor affecting 25(OH)D level,clinical attention should be paid to the correction of PCT level in MHD patients. Active vitamin D supplementation is also needed to improve 25(OH)D levels, reduce the incidence of falls, and continuously improve the quality of survival.
毛慧, 张丽, 赵倩, 贾英杰, 张秀娟, 吕彦辉. 血液净化治疗患者维生素D与微炎症及跌倒的关系研究[J]. 河北医学, 2023, 29(4): 667-672.
MAO Hui, ZHANG Li, ZHAO Qian, et al. Study of the Relationship between Vitamin D and Microinflammation and Falls in Patients Treated with Hemodialysis. HeBei Med, 2023, 29(4): 667-672.
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2023, Vol. 29 
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