2025年4月4日 星期五
首页        期刊介绍        编委会        投稿指南        期刊订阅        广告合作        联系我们        English
河北医学  2023, Vol. 29 Issue (4): 667-672    DOI: 10.3969/j.issn.1006-6233.2023.04.028
  临床研究 本期目录 | 过刊浏览 | 高级检索 |
血液净化治疗患者维生素D与微炎症及跌倒的关系研究
毛慧, 张丽, 赵倩, 贾英杰, 张秀娟, 吕彦辉
河北省承德市中心医院肾内科, 河北 承德 067000
Study of the Relationship between Vitamin D and Microinflammation and Falls in Patients Treated with Hemodialysis
MAO Hui, ZHANG Li, ZHAO Qian, et al
Chengde Central Hospital, Hebei Chengde 067000, China
全文: PDF (1253 KB)   HTML (1 KB) 
输出: BibTeX | EndNote (RIS)      
摘要 目的: 分析血液净化治疗患者25羟维生素D[25 hydroxyvitamin D ,25(OH)D]水平与微炎症及跌倒的关系。方法: 选取2020年1月至2020年6月在承德市中心医院行维持性血液透析(maintenance hemodialysis,MHD)治疗的患者80例,根据其25(OH)D水平分为25(OH)D低水平组和正常水平组,收集患者的一般资料,如性别、年龄、透析龄、身高、体重、原发病、血液净化方式、近1年跌倒发生情况,并化验血降钙素原(procalcitonin,PCT)、血红蛋白(Haemoglobin,Hb)、血浆白蛋白(Albumin,Alb)、血钙(Calcium,Ca)、血磷(Phosphorus,P)、甲状旁腺激素(parathyroid hormone,PTH)、甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)等指标,通过Pearson相关性分析、多元线性回归及二元Logistic回归分析25(OH)D与PCT及跌倒之间的关系。结果: 两组患者PCT、TG、TC在25(OH)D正常水平组较25(OH)D低水平组降低,差异有统计学意义(P<0.05);两组患者Hb在25(OH)D正常水平组较25(OH)D低水平组升高,差异有统计学意义(P<0.05)。Pearson相关分析表明,PCT、TC与25(OH)D水平存在负相关性(P<0.05);多因素回归分析显示,PCT、TC是影响25(OH)D水平的危险因素(P<0.05),25(OH)D水平是跌倒的保护性因素(P<0.05)。结论: PCT对MHD患者的25(OH)D水平有影响,是影响25(OH)D水平的独立危险因素,临床中需关注对MHD患者PCT水平的纠正。同时需积极补充活性维生素D以改善25(OH)D水平,减少跌倒的发生,不断提高生存质量。
服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
关键词 维持性血液透析25羟维生素D降钙素原跌倒微炎症    
AbstractObjective: To analyze the relationship between 25 hydroxyvitamin D, microinflammation and fall in patients treated with hemodialysis. Methods: A total of 80 patients receiving maintenance hemodialysis (MHD) treatment in Chengde Central Hospital from January 2020 to June 2020 were divided into 25(OH)D low group and normal group according to their 25(OH)D level. Gender, age, dialysis age, height, weight, primary disease ,blood purification method of the patients and the occurrence of falls in the past one year were recorded. Blood procalcitonin (PCT), haemoglobin (Hb), blood albumin, blood calcium, blood phosphorus, parathyroid hormone, triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol and other indicators were tested. The relationship between 25(OH)D, PCT and fall was analyzed by Pearson correlation analysis,multiple linear regression and binary Logistic analysis. Results: The level of PCT, TG and TC in 25 (OH) D normal group were lower than those in 25 (OH) D low group, and the differences were statistically significant (P<0.05). The level of Hb in the 25 (OH) D normal group was higher than that in the 25(OH)D low group, and the difference was statistically significant (P<0.05). Pearson correlation analysis showed that there was a negative correlation between PCT,TC and 25(OH)D level. Multivariate regression analysis showed that PCT and TC were independent influencing factors of 25(OH)D level, and 25(OH)D level was an protective factor affecting fall in MHD patients. Conclusion: PCT plays an important role in the 25(OH)D level of MHD patients, it is an independent risk factor affecting 25(OH)D level,clinical attention should be paid to the correction of PCT level in MHD patients. Active vitamin D supplementation is also needed to improve 25(OH)D levels, reduce the incidence of falls, and continuously improve the quality of survival.
Key wordsMaintenance hemodialysis    25 hydroxyvitamin D    Procalcitonin    Fall    Microinflammation
    
基金资助:河北省承德市科技计划项目,(编号:202002A011)
通讯作者: 吕彦辉   
引用本文:   
毛慧, 张丽, 赵倩, 贾英杰, 张秀娟, 吕彦辉. 血液净化治疗患者维生素D与微炎症及跌倒的关系研究[J]. 河北医学, 2023, 29(4): 667-672.
MAO Hui, ZHANG Li, ZHAO Qian, et al. Study of the Relationship between Vitamin D and Microinflammation and Falls in Patients Treated with Hemodialysis. HeBei Med, 2023, 29(4): 667-672.
链接本文:  
http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2023.04.028     或     http://www.hbyxzzs.cn/CN/Y2023/V29/I4/667
冀ICP备2025106803号    冀公网安备13080202000786号
版权所有 © 2016 《河北医学》杂志社
本系统由北京玛格泰克科技发展有限公司设计开发