严重程度痤疮患者血清25羟维生素D水平及其与IL-8 TNF-α TLR2的相关性

doi:10.3969/j.issn.1006-6233.2023.04.010

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摘要 目的: 探讨不同严重程度痤疮患者血清25羟维生素D水平与白细胞介素-8(IL-8)、肿瘤坏死因子(TNF-α)、Toll样受体2(TLR2)的相关性。方法: 选取2019年10月至2021年12月在本院收治的218例痤疮患者为痤疮组,所有患者均行血清学检测,根据pillsbury分级分为Ⅰ级组、Ⅱ级组、Ⅲ级组和Ⅳ级,随机选取同期218例健康体检人员为对照组。比较痤疮组和对照组血清IL-8、TNF-α、TLR2和25羟维生素D水平;比较不同pillsbury分级患者血清IL-8、TNF-α、TLR2和25羟维生素D水平;采用Pearson相关性分析痤疮组患者血清25羟维生素D水平与血清IL-8、TNF-α、TLR2水平的相关性;采用Spearman相关性分析痤疮组患者pillsbury分级与血清IL-8、TNF-α、TLR2、25羟维生素D水平的相关性。结果: 痤疮组患者血清IL-8、TNF-α、TLR2和25羟维生素D水平平均高于对照组(P<0.05);痤疮IV级组患者血清IL-8、TNF-α、TLR2和25羟维生素D水平高于Ⅰ级组、Ⅱ级组、Ⅲ级组;Ⅲ级组患者血清IL-8、TNF-α、TLR2和25羟维生素D水平高于Ⅰ级组、Ⅱ级组;Ⅱ级组患者血清IL-8、TNF-α、TLR2和25羟维生素D水平高于I级组(P<0.05);Pearson相关性分析显示,痤疮组患者血清25羟维生素D水平与血清IL-8、TNF-α、TLR2水平均呈正相关(P<0.05);Spearman相关性分析显示,痤疮组患者pillsbury分级与血清IL-8、TNF-α、TLR2、25羟维生素D水平均呈正相关(P<0.05)。结论: 痤疮患者血清25羟维生素D水平与炎症因子和痤疮严重程度具有相关性,可用于临床评估病情进展。

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关键词 ：痤疮, 25羟维生素D, 白细胞介素-8, 肿瘤坏死因子, Toll样受体2

Abstract：Objective: To explore the correlation between serum 25-hydroxyvitamin D and interleukin-8 (IL-8), tumor necrosis factor (TNF-α), Toll-like receptor 2 (TLR2) in patients with different severity of acne. Methods: A total of 218 patients with acne admitted to the hospital were enrolled as acne group between October 2019 and December 2021. All underwent serological tests. According to pillsbury grading, they were divided into grade I group, grade II group, grade III group and grade IV group. A total of 218 healthy controls during the same period were randomly enrolled as control group. The levels of serum IL-8, TNF-α, TLR2 and 25-hydroxyvitamin D were compared between acne group and control group, and among patients with different pillsbury grading. The correlation between serum 25-hydroxyvitamin D and IL-8, TNF-α, TLR2 was analyzed by Pearson correlation analysis. The correlation between pillsbury grading and serum IL-8, TNF-α, TLR2, 25-hydroxyvitamin D was analyzed by Spearman correlation analysis. Results: The levels of serum IL-8, TNF-α, TLR2 and 25-hydroxyvitamin D in acne group were significantly higher than those in control group (P<0.05). The levels of serum IL-8, TNF-α, TLR2 and 25-hydroxyvitamin were the highest in grade IV group, followed by grade III group, grade II group and grade I group (P<0.05). Pearson correlation analysis showed that level of serum 25-hydroxyvitamin D was positively correlated with levels of serum IL-8, TNF-α and TLR2 (P<0.05). Spearman correlation analysis showed that pillsbury grading was positively correlated with levels of serum IL-8, TNF-α, TLR2 and 25-hydroxyvitamin D (P<0.05). Conclusion: Serum 25-hydroxyvitamin D levels in acne patients are correlated with inflammatory factors and acne severity and can be used for clinical assessment of disease progression.

Key words： Acne 25-hydroxyvitamin D Interleukin-8 Tumor necrosis factor Toll-like receptor 2

基金资助:山东省烟台市科技计划项目,(编号:2021YD058)

通讯作者: 朱爱青

引用本文:

张小芳, 高军, 姜慧, 孙雪梅, 朱爱青. 严重程度痤疮患者血清25羟维生素D水平及其与IL-8 TNF-α TLR2的相关性[J]. 河北医学, 2023, 29(4): 578-582.
ZHANG Xiaofang, GAO Jun, JIANG Hui, et al. Level of Serum 25-Hydroxyvitamin D and Its Correlation with IL-8 TNF-α and TLR2 in Patients with Different Severity of Acne. HeBei Med, 2023, 29(4): 578-582.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2023.04.010 或 http://www.hbyxzzs.cn/CN/Y2023/V29/I4/578