肺纤维化合并肺气肿患者血清IGF-1 VEGF MMP-9表达变化及其与肺功能水平的相关性分析

doi:10.3969/j.issn.1006-6233.2023.03.08

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摘要 目的: 探讨肺纤维化合并肺气肿(CPFE)患者血清胰岛素样生长因子-1(IGF-1)、血管内皮生长因子(VEGF)、基质金属蛋白酶9(MMP-9)表达及其与肺功能的相关性分析。方法: 选取本院2015年1月至2021年12月58例CPFE患者纳入CPFE组,另选取30例单纯肺纤维化患者纳入肺纤维化组,30例单纯肺气肿患者纳入肺气肿组,30例健康体检者纳入对照组,检测血清IGF-1、VEGF、MMP-9水平,比较各组IGF-1、VEGF、MMP-9水平差异,分析CPFE组患者血清IGF-1、VEGF、MMP-9水平与肺功能指标[第1秒用力肺活量(FEV1)、用力肺活量(FVC)、一秒率(FEV1/FVC)]、血气指标[动脉血氧分压、二氧化碳分压(PaO₂、PaCO₂)]的关系。结果: 比较四组患者血清IGF-1、VEGF、MMP-9表达水平,肺纤维化组>CPFE组>肺气肿组>对照组(P<0.05);CPFE组PaO₂水平低于肺纤维化组与肺气肿组(P<0.05);CPFE组肺功能指标FEV1/FVC水平低于肺纤维化组与肺气肿组(P<0.05);CPFE组患者血清IGF-1、VEGF、MMP-9与血氧分压指标PaO₂呈现负相关(r=-0.379、-0.357、-0.283,均P<0.05),与PaCO₂呈现正相关(r=0.394、0.302、0.330,均P<0.05);CPFE组患者血清IGF-1、VEGF、MMP-9与肺功能指标FEV1、FEV1/FVC水平呈现负相关(r=-0.301、-0.246、-0.251、-0.411、-0.373、-0.310,均P<0.05),与FVC水平呈现正相关(r=0.271、0.253、0.234,均P<0.05)。结论: CPFE患者血清IGF-1、VEGF、MMP-9呈高表达,且其高表达状态与肺功能呈现负相关,与血氧分压水平呈现正相关,在一定程度上可反映患者肺功能以及通气功能受限程度。

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	戴晓瑛
	王志峰
	颜洪顺
	符之月

关键词 ：肺纤维化, 肺气肿, 病情, 胰岛素样生长因子-1, 血管内皮生长因子, 基质金属蛋白酶9

Abstract：Objective: To explore the correlation between serum insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9) levels and disease severity in patients with combined pulmonary fibrosis and emphysema (CPFE). Methods: A total of 58 patients with CPFE in the hospital were enrolled as CPFE group, 30 patients with pulmonary fibrosis were enrolled as pulmonary fibrosis group, 30 patients with simple emphysema were enrolled as emphysema group, and 30 healthy controls were enrolled as control group between January 2015 and December 2021. The levels of serum IGF-1, VEGF and MMP-9 were detected, and their differences in different groups were compared. The relationship between serum IGF-1, VEGF, MMP-9 and pulmonary function indexes [forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), FEV1/FVC], blood gas indexes [partial pressure of arterial blood oxygen (PaO₂), partial pressure of carbon dioxide (PaCO₂)] was analyzed. Results: The levels of serum IGF-1, VEGF and MMP-9 were the highest in pulmonary fibrosis group, followed by CPFE group, emphysema group and control group (P<0.05). PaO₂ level in CPFE group was lower than that in pulmonary fibrosis group and emphysema group (P<0.05), and FEV1/FVC was lower than that in pulmonary fibrosis group and emphysema group (P<0.05). The levels of serum IGF-1, VEGF and MMP-9 was negatively correlated with PaO₂ (r=-0.379, -0.357, -0.283, P<0.05), while positively correlated with PaCO₂ (r=0.394, 0.302, 0.330, P<0.05). The levels of serum IGF-1, VEGF and MMP-9 was negatively correlated with FEV1 and FEV1/FVC (r=-0.301, -0.246, -0.251, -0.411, -0.373, -0.310, P<0.05), while positively correlated with FVC (r=0.271, 0.253, 0.234, P<0.05). Conclusion: The expression levels of serum IGF-1, VEGF and MMP-9 are high in CPFE patients, which are negatively correlated with lung function, while positively correlated with partial pressure of blood oxygen. They can reflect pulmonary function and limitation degree of ventilation function to a certain extent.

Key words： Pulmonary fibrosis Emphysema Condition Insulin-like growth factor-1 Vascular endothelial growth factor Matrix metalloproteinase-9

基金资助:海南省卫生健康行业科研项目,(编号:19A200093)

引用本文:

戴晓瑛, 王志峰, 颜洪顺, 符之月. 肺纤维化合并肺气肿患者血清IGF-1 VEGF MMP-9表达变化及其与肺功能水平的相关性分析[J]. 河北医学, 2023, 29(3): 393-397.
DAI Xiaoying, WANG Zhifeng, YAN Hongshun, et al. Correlation between Serum IGF-1 VEGF MMP-9 Levels and Disease Severity in Patients with Combined Pulmonary Fibrosis and Emphysema. HeBei Med, 2023, 29(3): 393-397.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2023.03.08 或 http://www.hbyxzzs.cn/CN/Y2023/V29/I3/393

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