Effects of Sacubitril/Valsartan Sodium and Valsartan on Myocardial Enzymes, NT-proBNP and Inflammatory Factors in Elderly Patients with Coronary Heart Disease after PCI
ZHANG Zutao, LIAO Wei, ZHANG Nan, et al
Wuhan Asia Heart Hospital, Hubei Wuhan 430022, China
Abstract：Objective: To compare the effects of sacubitril/valsartan sodium and valsartan on myocardial enzymes, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and inflammatory factors in elderly patients with coronary heart disease after percutaneous coronary intervention (PCI). Methods: The data of 139 elderly patients with coronary heart disease after PCI in our hospital from January 2020 to January 2022 were retrospectively collected, of which 40 patients received conventional western medicine treatment after PCI for coronary heart disease (control group), 50 treated with Shakubatrac valsartan sodium on the basis of routine treatment (Shakubatrac valsartan sodium group), and 49 treated with valsartan on the basis of routine treatment (valsartan group). The 3 groups were compared in terms of cardiac function, myocardial enzymes, NT-proBNP, and inflammatory factors. The incidence of major adverse cardiac events (MACE) was recorded. Results: The difference in left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD), and left ventricular end-diastolic diameter (LVEDD) before and after treatment in the sakubactrovalsartan sodium group were higher than those in valsartan group and the control group (P<0.05). The difference between creatine kinase (CK), creatine kinase isoenzyme (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST), NT-proBNP, tumor necrosis factor (TNF)-α and interleukin (IL)-6 before and after treatment in sakubactrovalsartan sodium group were higher than those in valsartan group and the control group (P<0.05). The total incidence of MACE in the sakubactrovalsartan sodium group, valsartan group, and control group were 6.00%, 14.29% and 27.50%, the difference between the 3 groups was statistically significant (P<0.05). Conclusion: For elderly patients with coronary heart disease after PCI, sacubitril/valsartan sodium treatment can improve cardiac function, restore myocardial enzymes, lower the levels of NT-proBNP and inflammatory factors, and reduce the risk of MACE after the operation.
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2023, Vol. 29 
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