Abstract：Objective: To investigate the relationship between microangiopathopathy and retinal vessel diameter in type 2 diabetes mellitus (T2DM). Methods: A total of 213 patients with T2DM hospitalized in Chengde Central Hospital from 2018 to 2019 were collected. The retinal vessel diameter was measured semi-automatically according to fundus photography, and the central retinal artery equivalent value (CRAE), central retinal vein equivalent value (CRVE), and arteriovenous ratio (AVR) were calculated. Patients were divided into 4 groups according to different microangiopathopathy: 94 cases in the NC group, 69 cases in the DR group, 24 cases in the DN group, and 26 cases in the DNR group. The basic clinical data of the 4 groups of patients were compared, and the vascular differences among the non-proliferative DR patients at different stages were compared. Disordered multiple logistic regression was used to analyze the relationship between microangiopathopathy and retinal vessel diameter. Results: In the NC group, DR group, DN group, and DNR group, the CRVEs were (257.05±22.40)μm, (266.97±23.66)μm, (270.24±17.67)μm and (278.64±25.91)μm, respectively. The venous diameter increased gradually and the difference was statistically significant (P<0.001). AVRs were (0.69±0.06), (0.66±0.06), (0.65±0.06) and (0.64±0.08), respectively. The arteriovenous ratio decreased gradually and the difference was statistically significant (P<0.001). Among 210 patients with non-proliferative DR, there were 117 cases in the DR-free group, 39 cases in the DRⅠ group, 32 cases in the DRⅡ group, and 22 cases in the DRⅢ group. Spearman correlation analysis showed that CRVE was positively correlated with the non-proliferative DR stage (r=0.235, P=0.001), and AVR was negatively correlated with the non-proliferative DR stage (r=-0.217, P=0.002). Disordered multiple logistic regression analysis showed that CRVE and AVR were significantly correlated with microangiopathy. The increase in retinal vein diameter and decrease in the arteriovenous ratio are independent risk factors for diabetic microangiopathies. Conclusion: The increase in retinal vein diameter and the decrease in arteriovenous ratio predict the severity of systemic microcirculation in T2DM patients.
王梅, 姜超, 裴存文, 刘磊, 段运动. 2型糖尿病患者微血管病变与视网膜血管直径的相关性[J]. 河北医学, 2023, 29(2): 339-344.
WANG Mei, JIANG Chao, et al. Correlation between Microangiopathy and Retinal Vessel Diameter in Patients with Type 2 Diabetes Mellitus. HeBei Med, 2023, 29(2): 339-344.
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2023, Vol. 29 
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