Analysis of the Relationship between Left Ventricular Systolic Function and Cardiac Function Grading and Liver Stiffness in Patients with Liver Cirrhosis
GUO Hongli, LIANG Hongliang, ZHANG Tao, et al
363 Hospital / Chengdu 363 Hospital Affiliated to Southwest Medical University, Sichuan Chengdu 610041, China
Abstract：Objective: To explore the relationship between left ventricular systolic function and cardiac function grading and liver stiffness in patients with liver cirrhosis. Methods: From July 2020 to June 2022, 47 patients with liver cirrhosis were selected as the research subjects, and 40 healthy subjects undergoing physical examination were enrolled as the control group. The cardiac function indicators (LVEDD, LVESD, LVEDV, LVESV, LVEF) were detected by iu-Ilite ultrasound diagnostic apparatus (Philips Company, Netherlands), and aixplorer color Doppler ultrasound was adopted to detect the liver stiffness, and the correlation of left ventricular systolic function indicators with cardiac function grading and liver stiffness was analyzed. Results: The LVEDV and LVESV of the liver cirrhosis group were higher than those of the control group [(96.04±7.73) mL vs (91.26±7.89) mL, (36.53±7.12) mL vs (31.02±7.58) mL] while the LVEF was lower than that of the control group [(0.62±0.08)% vs (0.66±0.10)%,P<0.05]. According to the different NYHA cardiac function grading in patients with liver cirrhosis, they were divided into grade I (20 cases), grade II (16 cases), grade III (11 cases), and grade IV (5 cases). The LVEDD, LVEDV, and LVESV of patients with NYHA cardiac function grades III and IV were greater than those of patients with grades I and II [(4.58±0.38) cm vs (4.34±0.35) cm, (98.52±6.49) mL vs (94.24±7.05) mL, (39.06±6.34) mL vs (35.22±6.05) mL] while the LVEF was less than that of patients with grades I and II [(0.60±0.04)% vs (0.63±0.05)%,P<0.05].The LVESV of patients with liver cirrhosis was positively correlated with cardiac function grading while the LVEF was negatively correlated with cardiac function grading (r=0.198, -0.206,P<0.05). According to Child-Pugh grading, patients with liver cirrhosis were classified into grade A (15 cases), grade B (20 cases), and grade C (12 cases), and the LVEDV, LVESV, and liver stiffness of patients with liver cirrhosis were increased with the increase of liver function grading, while the LVEF was decreased with the increase of liver function grading (P<0.05). LVESV was positively correlated with liver stiffness, and LVEF was negatively correlated with liver stiffness in patients with liver cirrhosis (P<0.05). Conclusion: The left ventricular systolic function is decreased in patients with liver cirrhosis, and the left ventricular systolic function indicators are related to cardiac function grading and liver stiffness.
郭洪礼, 梁红亮, 张涛, 汤甜. 肝硬化患者左心室收缩功能与心功能分级肝脏硬度的关系分析[J]. 河北医学, 2023, 29(2): 285-289.
GUO Hongli, LIANG Hongliang, ZHANG Tao, et al. Analysis of the Relationship between Left Ventricular Systolic Function and Cardiac Function Grading and Liver Stiffness in Patients with Liver Cirrhosis. HeBei Med, 2023, 29(2): 285-289.
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2023, Vol. 29 
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