七叶皂苷钠联合骨肽注射液对老年跟骨骨折术后肢体肿胀的疗效及血清BALP BGP的影响

doi:10.3969/j.issn.1006-6233.2023.02.011

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摘要 目的: 探讨七叶皂苷钠联合骨肽注射液对老年跟骨骨折术后肢体肿胀的疗效及血清骨碱性磷酸酶(Bone alkaline phosphatase,BALP)、骨钙素(osteocalcin,BGP)的影响。方法: 选择2018年4月至2020年10月于我院治疗的老年跟骨骨折术后肢体肿胀患者102例,按以奇偶数字随机分配法分两组,对照组采用七叶皂苷钠10mg,qd;试验组采用七叶皂苷钠10mg,qd联合骨肽注射液10mL,qd,持续治疗2周。分别记录小腿周径差、患肢肿胀度评分、视觉模拟量表评分(Visual analogue scale,VAS)及血清BALP、BGP水平,对两组临床疗效进行比对。结果: 与对照组的临床有效率86.27%进行比较,试验组有效率96.08%较高(P<0.05)。与治疗前比,两组治疗后小腿周径差、肿胀度评分、VAS评分均降低,与对照组相比,试验组小腿周径差、肿胀度评分、VAS评分治疗前后差值较高,差异有统计学意义(P<0.05)。相比治疗前,疗后血清BALP、BGP水平增高(P<0.05);与对照组进行比较,试验组血清BALP、BGP水平治疗前后差值较高,差异有统计学意义(P<0.05)。结论: 七叶皂苷钠联合骨肽注射液对老年跟骨骨折术后肢体肿胀的疗效确切,可改善骨代谢,且安全性高,值得推广。

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关键词 ：七叶皂苷钠, 骨肽注射液, 老年跟骨骨折, 术后肢体肿胀, BALP, BGP

Abstract：Objective: To investigate the effect of sodium aescinate combined with bone peptide injection on limb swelling after calcaneal fracture surgery in elderly patients and the influence of serum bone alkaline phosphatase (BALP) and Osteocalcin (BGP). Methods: A total of 102 elderly patients with limb swelling after calcaneal fracture treated in our hospital from April 2018 to October 2020 were selected and divided into 2 groups using random number table method. The control group received sodium aescinate 10mg,qd; the treatment group was treated with sodium aescinate 10mg, qd combined with bone peptide injection 10ml, qd, and the 2 groups were treated for 2 weeks. The leg circumference difference, limb swelling score, visual analogue scale (VAS) score, serum BALP and BGP levels were recorded, and the clinical efficacy was compared between the two groups. Results: Compared with the clinical effective rate of 86.27% in the control group, the effective rate of the experimental group was 96.08% (P<0.05). Compared with before treatment, the difference of calf circumference, swelling score and VAS score in the two groups were decreased after treatment. Compared with the control group, the difference of calf circumference difference, swelling score and VAS score before and after treatment in the experimental group were higher, and the differences were statistically significant (P<0.05). Compared with before treatment, serum BALP and BGP levels increased after treatment (P <0.05). Compared with the control group, the differences in serum BALP and BGP levels before and after treatment in the experimental group were higher, and the differences were statistically significant (P<0.05). Conclusion: Sodium aescinate combined with bone peptide injection has definite curative effect on limb swelling after calcaneal fracture surgery in the elderly, can improve bone metabolism, and has high safety, which is worthy of promotion.

Key words： Sodium aescinate Osteopeptide injection Senile calcaneal fracture Postoperative limb swelling BALP BGP

基金资助:陕西科技厅科学技术研究计划,(编号:2018kjxx33)

通讯作者: 李娅

引用本文:

谢婷, 李娅, 王宁, 梁一凡, 刘静, 李天青. 七叶皂苷钠联合骨肽注射液对老年跟骨骨折术后肢体肿胀的疗效及血清BALP BGP的影响[J]. 河北医学, 2023, 29(2): 236-242.
XIE Ting, LI Ya, WANG Ning, et al. Study on the Effect of Sodium Aescinate Combined with Bone Peptide Injection on Limb Swelling and Serum BALP and BGP in Elderly Patients after Calcaneal Fracture Surgery. HeBei Med, 2023, 29(2): 236-242.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2023.02.011 或 http://www.hbyxzzs.cn/CN/Y2023/V29/I2/236

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