Abstract：Objective: To investigate the effect of dapagliflozin treatment on cardiac function,quality of life and prognosis of patients with heart failure. Methods: A total of 250 patients with heart failure were randomly divided into experimental group and control group,of which 157 patients in the control group were treated with cardiac rehabilitation exercise and conventional anti-heart failure therapy,and 93 patients in the experimental group were treated with dapagliflozin 10mg once a day on the basis of the control group.Two groups were compared before and after treatment with serum N-terminal precursor brain natriuretic peptide (NT-proBNP),percentage of neutrophils (N%),hemoglobin (Hb),creatinine (Cr),left ventricular ejection fraction (LVEF),left ventricular end-diastolic diameter (LVEDD),Left ventricular wall relative thickness (RWT),6-minute walk experiment (6MWD),Minnesota Chronic Heart Failure Quality of Life Questionnaire (MLHFQ),and follow-up readmission rate and mortality within 6 months,and the differences of various indicators were compared and analyzed. Results: There were no significant differences between in NT-proBNP,N%,Hb,Cr,LVEF,LVEDD,RWT,6MWD and MLHFQ in the pre-intervention experimental group and control group (P>0.05). After the intervention,the serum NT-proBNP level,serum Cr level,LVEDD and 6MWD scores decreased (P<0.05),LVEF value and MLHFQ increased (P<0.05),all indicators after intervention in the experimental group were better than those in the control group. All patients were followed up.The readmission rates within six months in the experimental group and the control group were 16.13% and 22.93%,respectively.The difference was statistically significant between the two groups (P<0.05).The cardiogenic mortality rates of the two groups were 2.2% and 8.2%,respectively,and the difference between the two groups was statistically significant (P<0.05).There was no significant difference in the incidence of myocardial infarction and renal dysfunction between the two groups (P>0.05). Conclusion: Cardiac rehabilitation and dapagliflozin combination therapy can significantly improve the cardiopulmonary function and quality of life of patients,and is of great help to improve the long-term prognosis of patients with heart failure.
付祎姊, 武会志, 于海侠, 张若男. 达格列净对心力衰竭患者生活质量及预后的影响[J]. 河北医学, 2023, 29(11): 1911-1915.
FU Yizi, WU Huizhi, YU Haixia, et al. Effect of Dapagliflozin on Quality of Life and Prognosis in Patients with Heart Failure. HeBei Med, 2023, 29(11): 1911-1915.
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2023, Vol. 29 
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