Abstract：Objective: To investigate the expression of C1ql4 in breast cancer patients,and to analyze the relationship between C1ql4 and relevant clinicopathological features and prognosis of breast cancer. Methods: The study examined the expression of C1ql4 protein using immunohistochemistry in 143 breast cancer patients,with 20 breast fibroadenoma tissues serving as controls.Clinical and pathological data were collected,and the survival and prognosis of patients were monitored.The association between C1ql4 expression and prognosis was analyzed using Kaplan-Meier survival curves and multivariate Cox regression.Differences were considered statistically significant at P<0.05. Results: The positive expression rate of C1ql4 protein was 15% (3/20) in breast fibroadenoma and 98.6% (141/143) in breast cancer.In breast cancer tissues,C1ql4 low expression was observed in 47.6% (68/143) of cases,while high expression was found in 51.0% (73/143) of cases.C1ql4 expression was associated with various clinical factors,including tumor diameter,lymph node metastasis,TNM stage,and molecular subtypes (P<0.05).Patients in the high expression group of C1ql4 had a worse prognosis (P<0.05).Multivariate Cox regression analysis demonstrated that TNM stage,molecular subtyping,and high C1ql4 expression were independent risk factors for an unfavorable prognosis in breast cancer patients (P<0.05). Conclusion: C1ql4 is highly expressed in breast cancer tissues and is associated with prognosis and adverse pathological parameters.
张庆, 方昊天, 李青山, 徐繁. C1q类似蛋白4在乳腺癌中的表达及生存分析[J]. 河北医学, 2023, 29(11): 1842-1847.
ZHANG Qing, FANG Haotian, LI Qingshan, et al. Expression and Survival Analysis of C1q-Like Protein 4 in Breast Cancer. HeBei Med, 2023, 29(11): 1842-1847.
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2023, Vol. 29 
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